Fundus photography with subpixel registration of correlated laser speckle images

In this paper, we propose multiple modalities based on laser speckle correlation and image registration to enhance the visibility of the fundus without a scanning interferometric scenario, resulting in robustness against intra frame noises induced by inevitable movement. The experimental results showed, with the features from laser speckle contrast imaging (LSCI), that the quality of images obtained using a conventional imaging system could be enhanced. Moreover, by applying the image registration process, we successfully eliminated the inter frame blurring caused by eye movements in an in vivo experiment. The concept was proven when the image contrast of a vascular feature was improved by 1.00'–2.75'.