Functional dissociation within insular cortex: The effect of pre-stimulus anxiety on pain

Chia Shu Lin, Jen Chuen Hsieh, Tzu Chen Yeh, Shyh Yuan Lee, David M. Niddam*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Brain activity resulting from changes in pain intensity may not only reflect changes in stimulus intensity but also in emotional distress. The anterior and mid-posterior insula have been associated with anticipatory anxiety and sensory-discrimination, respectively. We hypothesized that the two sub-divisions would exhibit different post-stimulus responses to increased pain intensity after removing the confounding effect of anticipatory anxiety. Using functional magnetic resonance imaging, activity was found in the anterior and mid-posterior insula in response to both low- and high-intensity painful stimuli delivered at the same level of anticipatory anxiety. Anterior insula activity covaried with anxiety ratings. When the pain intensity increased and the level of anticipatory anxiety was matched, increased activity was found in the mid-posterior insula but not in the anterior insula. The increase in activity covaried with increased pain intensity. These findings support the notion that encoding in the anterior insula primarily depends on the pre-stimulus context, i.e.; anticipatory anxiety rather than the perceived pain intensity, and encoding in the mid-posterior insula is related to pain intensity changes.

Original languageEnglish
Pages (from-to)40-47
Number of pages8
JournalBrain Research
StatePublished - 1 Feb 2013


  • Anticipatory anxiety
  • Emotional distress
  • fMRI
  • Insula
  • Pain


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