Functional connectivity altering in hippocampus with closed-loop deep brain stimulation

Cihun Siyong Alex Gong*, Yuan Ting Tsai, Ji An Chen, Hsin Yi Lai, Wei Che Wei, You Yin Chen

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Hippocampus is considered as the main role of memory consolidation. Learning can be completed after memory consolidation. The thalamus plays an important role in consciousness. In past research had supported that that stimulation in the central lateral thalamus could enhance the learning behavioral. Here, we present an investigational platform including: an implanted sensing and stimulation components to collect data and run the closed-loop algorithm with real-time spectrum measurement. The prototyping system was demonstrated in a chronic animal model studying hippocampal dynamics. We used the platform to find the biomarker, that the theta (θ) spectral band power of local field potentials (LFPs) could be a control variable of interest when modulating hippocampal network state after central lateral thalamic stimulation. The platform is designed to be a flexible prototyping tool and could be used to develop improved mechanistic models and automated closed-loop systems for a variety of neurological disorders.

Original languageEnglish
Title of host publicationDigest of Technical Papers - IEEE International Conference on Consumer Electronics
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages7-8
Number of pages2
ISBN (Electronic)9781479938308
DOIs
StatePublished - 18 Sep 2014
Event1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014 - Taipei, Taiwan
Duration: 26 May 201428 May 2014

Publication series

NameDigest of Technical Papers - IEEE International Conference on Consumer Electronics
ISSN (Print)0747-668X

Conference

Conference1st IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2014
Country/TerritoryTaiwan
CityTaipei
Period26/05/1428/05/14

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