From genetic mutations to molecular basis of heart failure treatment: An overview of the mechanism and implication of the novel modulators for cardiac myosin

Yu Jen Chen, Chian Shiu Chien, Chern En Chiang, Chen Huan Chen, Hao Min Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Heart failure (HF) is a syndrome encompassing several important etiologies that lead to the imbalance between oxygen demand and supply. Despite the usage of guideline-directed medical therapy for HF has shown better outcomes, novel therapeutic strategies are desirable, especially for patients with preserved or mildly reduced left ventricular ejection fraction. In this regard, understanding the molecular basis for cardiomyopathies is expected to fill in the knowledge gap and generate new therapies to improve prognosis for HF. This review discusses an evolutionary mechanism designed to regulate cardiac contraction and relaxation through the most often genetically determined cardiomyopathies associated with HF. In addition, both the myosin inhibitor and myosin activator are promising new treatments for cardiomyopathies. A comprehensive review from genetic mutations to the molecular basis of direct sarcomere modulators will help shed light on future studies for a better characterization of HF etiologies and potential therapeutic targets.

Original languageEnglish
Article number6617
JournalInternational Journal Of Molecular Sciences
Volume22
Issue number12
DOIs
StatePublished - 2 Jun 2021

Keywords

  • Cardiac myosin
  • Dilated cardiomyopathy
  • Heart failure
  • Hereditary cardiomyopathy
  • Hypertrophic cardiomyopathy

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