Free space ultrasound guided fluorescence diffuse optical tomography

Pei An Lo, Huihua Kenny Chiang*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


A dual modality of free space fluorescence diffuse optical tomography and ultrasound imaging was demonstrated for the first time. The design combined a laser source with electron-multiplying charge-coupled device (EMCCD) on a rotation gantry with the structural information provided by an ultrasound transducer to reconstruct fluorescence diffuse optical tomography images. Optical data were obtained using a 660 nm laser at 16 angles in free space, and the fluorescence was in trans-illumination mode. In this work, a small feasibility study was performed to demonstrate that the fluorophore distribution could be recovered accurately and quantitatively using this imaging system.

Original languageEnglish
Title of host publicationPhotons Plus Ultrasound
Subtitle of host publicationImaging and Sensing 2017
EditorsAlexander A. Oraevsky, Lihong V. Wang
ISBN (Electronic)9781510605695
StatePublished - 2017
EventPhotons Plus Ultrasound: Imaging and Sensing 2017 - San Francisco, United States
Duration: 29 Jan 20171 Feb 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferencePhotons Plus Ultrasound: Imaging and Sensing 2017
Country/TerritoryUnited States
CitySan Francisco


  • Fluorescence
  • Reconstruction
  • Tomography
  • Ultrasound


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