Formal Total Synthesis of l -Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System

Shinsuke Inuki, Keisuke Sato, Takahide Fukuyama, Ilhyong Ryu, Yukari Fujimoto*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    26 Scopus citations

    Abstract

    A formal total synthesis of l-ossamine was achieved. The key feature of the synthesis was the decarboxylative functionalization of a threonine derivative using visible-light-mediated photoredox catalysis. This reaction was implemented in a flow reactor, allowing for the efficient conversion to the desired product.

    Original languageEnglish
    Pages (from-to)1248-1253
    Number of pages6
    JournalJournal of Organic Chemistry
    Volume82
    Issue number2
    DOIs
    StatePublished - 20 Jan 2017

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