FooDisNET: A database of food-compound-protein-disease associations

Chu Yun Lin, Jung Yu Lee, Sing Han Huang, Yen Chao Hsu, Nung Yu Hsu, Jinn Moon Yang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

Natural compounds and nutrients in plants are beneficial to human health and reduce the risk of diseases. These compounds can directly or indirectly act on specific proteins to regulate biochemical pathways and affect disease progression or prevent the occurrence of chronic diseases. Several databases provide information about the ingredients of various plants, Chinese medicine, and the plant-target associations. However, there is still a lack of a database linking food, compounds, proteins, and diseases. Here, we propose a FooDisNET database to provide food-compound-protein-disorder connections. FooDisNET contains 6,329 foods, 53,920 compounds, and 22,865 target proteins, of which 4,092 target proteins are associated with 18,689 disorders. Based on our scoring strategy, we constructed a user-friendly website that enables the user to query the associations from four perspectives, namely foods, compounds, proteins, and disorders. The score reflects the prevalence of foods, the rarity of compounds, the specificity of proteins, and the universality of disorders to describe food-compound-protein-disorder interaction networks. We believe that the FooDisNET database not only assists general uses to investigate food ingredients that are beneficial to their health but also helps the analysis of the role of natural compounds in the drug discovery and development process.

Original languageEnglish
Title of host publicationProceedings - IEEE 20th International Conference on Bioinformatics and Bioengineering, BIBE 2020
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages190-195
Number of pages6
ISBN (Electronic)9781728195742
DOIs
StatePublished - Oct 2020
Event20th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2020 - Virtual, Cincinnati, United States
Duration: 26 Oct 202028 Oct 2020

Publication series

NameProceedings - IEEE 20th International Conference on Bioinformatics and Bioengineering, BIBE 2020

Conference

Conference20th IEEE International Conference on Bioinformatics and Bioengineering, BIBE 2020
Country/TerritoryUnited States
CityVirtual, Cincinnati
Period26/10/2028/10/20

Keywords

  • diet and health
  • disease prevention
  • drug development
  • food-disease interaction network
  • natural products
  • phytochemicals
  • query performance

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