TY - JOUR
T1 - FNIH-defined Sarcopenia Predicts Adverse Outcomes among Community-Dwelling Older People in Taiwan
T2 - Results from I-Lan Longitudinal Aging Study
AU - Tang, Ting Ching
AU - Hwang, An Chun
AU - Liu, Li Kuo
AU - Lee, Wei Ju
AU - Chen, Liang Yu
AU - Wu, Yi Hui
AU - Huang, Chung Yu
AU - Hung, Cheng Hao
AU - Wang, Chih Jen
AU - Lin, Ming Hsien
AU - Peng, Li Ning
AU - Chen, Liang Kung
N1 - Publisher Copyright:
© The Author(s) 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2018/5/9
Y1 - 2018/5/9
N2 - Background To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults. Methods Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study. Data for subjects aged 65 years and older were obtained for study. The outcome measures were all-cause mortality and a composite adverse outcome which includes hospitalizations, emergency department visits, institutionalization, and falls. Results Data of 728 eligible elderly participants (73.4 ± 5.4 years; 52.9% males) were analyzed. The prevalence of FNIH-diagnosed sarcopenia was 9.5%: 11.9% males; 6.7% females. Participants having FNIH-defined sarcopenia were considerably older, frailer, more obese, with poorer physical performance than nonsarcopenic subjects (All p <.001); during mean follow-up of 32.9 ± 8.8 months, they also had 3.8 times higher risk of dying, independent of age, sex, multimorbidity, cognitive function, and nutritional status (hazard ratio = 3.8; 95% confidence interval = 1.26-11.45; p =.018). Moreover, sarcopenia defined by grip strength-BMI ratio (Weak BMI) showed stronger association with composite adverse outcomes than traditional handgrip strength (hazard ratio = 1.99; 95% confidence interval = 1.01-3.93; p =.047 vs hazard ratio = 1.80; 95% confidence interval = 0.89-3.62; p =.102 in fully-adjusted model). Conclusion Among community-dwelling older people in Taiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.
AB - Background To evaluate the predictive validity of sarcopenia defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project among Asian older adults. Methods Data of the I-Lan Longitudinal Aging Study were obtained for analysis. Overall, 1,839 community-dwelling people aged 50 years and older, capable of completing a 6-m walk, with life expectancy of more than 6 months, and not institutionalized at time of data collection were enrolled for study. Data for subjects aged 65 years and older were obtained for study. The outcome measures were all-cause mortality and a composite adverse outcome which includes hospitalizations, emergency department visits, institutionalization, and falls. Results Data of 728 eligible elderly participants (73.4 ± 5.4 years; 52.9% males) were analyzed. The prevalence of FNIH-diagnosed sarcopenia was 9.5%: 11.9% males; 6.7% females. Participants having FNIH-defined sarcopenia were considerably older, frailer, more obese, with poorer physical performance than nonsarcopenic subjects (All p <.001); during mean follow-up of 32.9 ± 8.8 months, they also had 3.8 times higher risk of dying, independent of age, sex, multimorbidity, cognitive function, and nutritional status (hazard ratio = 3.8; 95% confidence interval = 1.26-11.45; p =.018). Moreover, sarcopenia defined by grip strength-BMI ratio (Weak BMI) showed stronger association with composite adverse outcomes than traditional handgrip strength (hazard ratio = 1.99; 95% confidence interval = 1.01-3.93; p =.047 vs hazard ratio = 1.80; 95% confidence interval = 0.89-3.62; p =.102 in fully-adjusted model). Conclusion Among community-dwelling older people in Taiwan, participants with FNIH-defined sarcopenia had a significantly greater risk of all-cause mortality and composite falls, emergency department visits, institutionalization, and hospitalization.
KW - Aging
KW - All-cause mortality
KW - Sarcopenia
KW - The foundation for the National Institute of Health Biomarkers Consortium Sarcopenia Project
UR - http://www.scopus.com/inward/record.url?scp=85045461904&partnerID=8YFLogxK
U2 - 10.1093/gerona/glx148
DO - 10.1093/gerona/glx148
M3 - Article
C2 - 28977377
AN - SCOPUS:85045461904
SN - 1079-5006
VL - 73
SP - 828
EP - 834
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 6
ER -