FNDC3B promotes cell migration and tumor metastasis in hepatocellular carcinoma

Chin Hui Lin, Yao Wen Lin, Ying Chun Chen, Chen Chung Liao, Yuh Shan Jou, Ming Ta Hsu, Chian Feng Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Recurrence and metastasis are common in hepatocellular carcinoma (HCC) and correlate with poor prognosis. We investigated the role of fibronectin type III domain containing 3B (FNDC3B) in HCC metastasis. Overexpression of FNDC3B in HCC cell lines enhanced cell migration and invasion. On the other hand, knockdown of FNDC3B using short-hairpin RNA reduced tumor nodule formation in both intra- and extrahepatic metastasis. High levels of FNDC3B were observed in metastatic HCCs and correlated with poor patient survival and shorter recurrence time. Mutagenesis and LC-MS/MS analyses showed that FNDC3B promotes cell migration by cooperating with annexin A2 (ANXA2). Furthermore, FNDC3B and ANXA2 expression correlated negatively with patient survival. Our results indicate that FNDC3B behaves like an oncogene by promoting cell migration. This suggests FNDC3B could serve as a biomarker and therapeutic target for HCC metastasis.

Original languageEnglish
Pages (from-to)49498-49508
Number of pages11
JournalOncotarget
Volume7
Issue number31
DOIs
StatePublished - 2016

Keywords

  • FNDC3B
  • Hepatocellular carcinoma
  • Metastasis

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