@article{bbbf4c12be8047b89e957b296f05fd0c,
title = "FMRI hemodynamics accurately reflects neuronal timing in the human brain measured by MEG",
abstract = "Neuronal activation sequence information is essential for understanding brain functions. Extracting such timing information from blood oxygenation level dependent (BOLD) fMRI is confounded by interregional neurovascular differences and poorly understood relations between BOLD and electrophysiological response delays. Here, we recorded whole-head BOLD fMRI at 100. ms resolution and magnetoencephalography (MEG) during a visuomotor reaction-time task. Both methods detected the same activation sequence across five regions, from visual towards motor cortices, with linearly correlated interregional BOLD and MEG response delays. The smallest significant interregional BOLD delay was 100. ms; all delays ≥. 400. ms were significant. Switching the order of external events reversed the sequence of BOLD activations, indicating that interregional neurovascular differences did not confound the results. This may open new avenues for using fMRI to follow rapid activation sequences in the brain.",
keywords = "BOLD, Hemodynamics, Inverse imaging, Latency, Neuronal timing, Neurovascular coupling",
author = "Lin, {Fa Hsuan} and Thomas Witzel and Tommi Raij and Jyrki Ahveninen and {Wen-Kai Tsai}, Kevin and Chu, {Yin Hua} and Chang, {Wei Tang} and Aapo Nummenmaa and Polimeni, {Jonathan R.} and Kuo, {Wen Jui} and Hsieh, {Jen Chuen} and Rosen, {Bruce R.} and Belliveau, {John W.}",
note = "Funding Information: We are grateful for access to the MEG imaging resources at the Veteran General Hospital, Taipei, Taiwan, and the MRI resources at the National Yang-Ming University and National Taiwan University Hospital, Taipei, Taiwan. We also thank Academician Riitta Hari for comments, Chih-Che Chou and Yen-Hsiang Wang for technical support, and Nichole Eusemann for language editing. This work was supported by grants from the United States National Institutes of Health (NIH) ( R01HD040712 , R01NS037462 , R01NS048279 , P41RR014075 , R01MH083744 , R21DC010060 , R21EB007298 ), National Center for Research Resources , National Science Council, Taiwan ( NSC 101-2628-B-002-005-MY3 , NSC 100-2325-B-002-046 ), National Health Research Institute, Taiwan ( NHRI-EX102-10247EI ), and Academy of Finland ( 127624 and the FiDiPro program ). ",
year = "2013",
month = sep,
doi = "10.1016/j.neuroimage.2013.04.017",
language = "English",
volume = "78",
pages = "372--384",
journal = "NeuroImage",
issn = "1053-8119",
publisher = "Academic Press Inc.",
}