Flow Update for a Cossy Photocyclization

Takahide Fukuyama*, Yuki Fujita, Muhammad Abid Rashid, Ilhyong Ryu

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    13 Scopus citations

    Abstract

    A Cossy 5-exo-dig photocyclization of organohalides (X = Br, I) onto a C-C triple bond was studied using a flow photomicroreactor, which proceeded in a minute order of residence time. A deuterium labeling study supported the nonchain radical mechanism proposed by the Cossy group, in which a hydrogen source originates from a triethylamine cation radical. Scalable flow synthesis using a larger volume of flow reactor was also successful, providing 4 g of the product in high yield.

    Original languageEnglish
    Pages (from-to)5444-5446
    Number of pages3
    JournalOrganic Letters
    Volume18
    Issue number20
    DOIs
    StatePublished - 21 Oct 2016

    Fingerprint

    Dive into the research topics of 'Flow Update for a Cossy Photocyclization'. Together they form a unique fingerprint.

    Cite this