Flow of information underlying a tactile decision in mice

Nuo Li*, Zengcai V. Guo, Tsai Wen Chen, Karel Svoboda

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Motor planning allows us to conceive, plan, and initiate skilled motor behaviors. Motor planning involves activity distributed widely across the cortex. How this activity dynamically comes together to guide movement remains an unsolved problem. We study motor planning in mice performing a tactile decision behavior. Head-fixed mice discriminate object locations with their whiskers and report their choice by directional licking (“lick left”/“lick right”). A short-term memory component separates tactile “sensation” and “action” into distinct epochs. Using loss-of-function experiments, cell-type specific electrophysiology, and cellular imaging, we delineate when and how activity in specific brain areas and cell types drives motor planning in mice. Our results suggest that information flows serially from sensory to motor areas during motor planning. The motor cortex circuit maintains the motor plan during short-term memory and translates the motor plan into motor commands that drive the upcoming directional licking.

Original languageEnglish
Title of host publicationResearch and Perspectives in Neurosciences
PublisherSpringer Verlag
Number of pages7
StatePublished - 2016

Publication series

NameResearch and Perspectives in Neurosciences
ISSN (Print)0945-6082
ISSN (Electronic)2196-3096


Dive into the research topics of 'Flow of information underlying a tactile decision in mice'. Together they form a unique fingerprint.

Cite this