TY - JOUR
T1 - Finding the optimal deconvolution algorithm for MR perfusion in carotid stenosis
T2 - Correlations with angiographic cerebral circulation time
AU - Lin, Chung Jung
AU - Hung, Sheng Che
AU - Chang, Feng Chi
AU - Guo, Wan Yuo
AU - Luo, Chao Bao
AU - Kowarschik, Markus
AU - Chu, Wei Fa
AU - Liou, Adrian J.Y.Kang
N1 - Publisher Copyright:
© 2016 Elsevier Masson SAS.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Purpose: The aim of our study is to explore the impacts of different deconvolution algorithms on correlations between CBF, MTT, CBV, TTP, Tmax from MR perfusion (MRP) and angiography cerebral circulation time (CCT). Methods: Retrospectively, 30 patients with unilateral carotid stenosis, and available pre-stenting MRP and angiography were included for analysis. All MRPs were conducted in a 1.5-T MR scanner. Standard singular value decomposition, block-circulant, and two delay-corrected algorithms were used as the deconvolution methods. All angiographies were obtained in the same bi-plane flat-detector angiographic machine. A contrast bolus of 12 mL was administrated via angiocatheter at a rate of 8 mL/s. The acquisition protocols were the same for all cases. CCT was defined as the difference between time to peak from the cavernous ICA and the parietal vein in lateral view. Pearson correlations were calculated for CCT and CBF, MTT, CBV, TTP, Tmax. Results: The correlation between CCT and MTT was highest with Tmax (r = 0.65), followed by MTT (r = 0.60), CBF (r = -0.57), and TTP (r = 0.33) when standard singular value decomposition was used. No correlation with CBV was noted. Conclusions: MRP using a singular value decomposition algorithm confirmed the feasibility of quantifying cerebral blood flow deficit in steno-occlusive disease within the angio-room. This approach might further improve patient safety by providing immediate cerebral hemodynamics without extraradiation and iodine contrast.
AB - Purpose: The aim of our study is to explore the impacts of different deconvolution algorithms on correlations between CBF, MTT, CBV, TTP, Tmax from MR perfusion (MRP) and angiography cerebral circulation time (CCT). Methods: Retrospectively, 30 patients with unilateral carotid stenosis, and available pre-stenting MRP and angiography were included for analysis. All MRPs were conducted in a 1.5-T MR scanner. Standard singular value decomposition, block-circulant, and two delay-corrected algorithms were used as the deconvolution methods. All angiographies were obtained in the same bi-plane flat-detector angiographic machine. A contrast bolus of 12 mL was administrated via angiocatheter at a rate of 8 mL/s. The acquisition protocols were the same for all cases. CCT was defined as the difference between time to peak from the cavernous ICA and the parietal vein in lateral view. Pearson correlations were calculated for CCT and CBF, MTT, CBV, TTP, Tmax. Results: The correlation between CCT and MTT was highest with Tmax (r = 0.65), followed by MTT (r = 0.60), CBF (r = -0.57), and TTP (r = 0.33) when standard singular value decomposition was used. No correlation with CBV was noted. Conclusions: MRP using a singular value decomposition algorithm confirmed the feasibility of quantifying cerebral blood flow deficit in steno-occlusive disease within the angio-room. This approach might further improve patient safety by providing immediate cerebral hemodynamics without extraradiation and iodine contrast.
KW - Carotid stenosis
KW - Cerebral blood flow
KW - Cerebral circulation time
KW - Deconvolution algorithm
KW - MR perfusion
KW - Quantitative DSA
KW - Time density curve
UR - http://www.scopus.com/inward/record.url?scp=84962086579&partnerID=8YFLogxK
U2 - 10.1016/j.neurad.2016.02.002
DO - 10.1016/j.neurad.2016.02.002
M3 - Article
C2 - 27038737
AN - SCOPUS:84962086579
SN - 0150-9861
VL - 43
SP - 290
EP - 296
JO - Journal of Neuroradiology
JF - Journal of Neuroradiology
IS - 4
ER -