Finding the optimal deconvolution algorithm for MR perfusion in carotid stenosis: Correlations with angiographic cerebral circulation time

Chung Jung Lin, Sheng Che Hung, Feng Chi Chang, Wan Yuo Guo*, Chao Bao Luo, Markus Kowarschik, Wei Fa Chu, Adrian J.Y.Kang Liou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Purpose: The aim of our study is to explore the impacts of different deconvolution algorithms on correlations between CBF, MTT, CBV, TTP, Tmax from MR perfusion (MRP) and angiography cerebral circulation time (CCT). Methods: Retrospectively, 30 patients with unilateral carotid stenosis, and available pre-stenting MRP and angiography were included for analysis. All MRPs were conducted in a 1.5-T MR scanner. Standard singular value decomposition, block-circulant, and two delay-corrected algorithms were used as the deconvolution methods. All angiographies were obtained in the same bi-plane flat-detector angiographic machine. A contrast bolus of 12 mL was administrated via angiocatheter at a rate of 8 mL/s. The acquisition protocols were the same for all cases. CCT was defined as the difference between time to peak from the cavernous ICA and the parietal vein in lateral view. Pearson correlations were calculated for CCT and CBF, MTT, CBV, TTP, Tmax. Results: The correlation between CCT and MTT was highest with Tmax (r = 0.65), followed by MTT (r = 0.60), CBF (r = -0.57), and TTP (r = 0.33) when standard singular value decomposition was used. No correlation with CBV was noted. Conclusions: MRP using a singular value decomposition algorithm confirmed the feasibility of quantifying cerebral blood flow deficit in steno-occlusive disease within the angio-room. This approach might further improve patient safety by providing immediate cerebral hemodynamics without extraradiation and iodine contrast.

Original languageEnglish
Pages (from-to)290-296
Number of pages7
JournalJournal of Neuroradiology
Volume43
Issue number4
DOIs
StatePublished - 1 Jul 2016

Keywords

  • Carotid stenosis
  • Cerebral blood flow
  • Cerebral circulation time
  • Deconvolution algorithm
  • MR perfusion
  • Quantitative DSA
  • Time density curve

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