Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan

Jainn Jim Lin; Yi Fang Tu; Shyi Jou Chen; Yung Ting Kuo; Mei Jy Jeng; Mary Hsin-Ju Ko; Cheng Hsun Chiu

doi:10.1093/jpids/piac116

Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan

Jainn Jim Lin^*, Yi Fang Tu, Shyi Jou Chen, Yung Ting Kuo, Mei Jy Jeng, Mary Hsin-Ju Ko, Cheng Hsun Chiu

^*Corresponding author for this work

Institute of Emergency and Critical Care Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.

Original language	English
Pages (from-to)	99-103
Number of pages	5
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	12
Issue number	2
DOIs	https://doi.org/10.1093/jpids/piac116
State	Published - 1 Feb 2023

Keywords

COVID-19
Omicron BA.2
fulminant cerebral edema
hypercytokinemia
pediatric

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.",

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AU - Lin, Jainn Jim

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AU - Jeng, Mei Jy

AU - Hsin-Ju Ko, Mary

AU - Chiu, Cheng Hsun

PY - 2023/2/1

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AB - Acute fulminant cerebral edema in children following SARS-CoV-2 infection has been rarely reported. Such patients frequently demonstrate rapid progression and are usually fatal. In this retrospective study, we describe the detailed clinical, laboratory, and neuroimaging features of six fatal cases in Taiwan. All patients had shock initially, five showed rapid progression to multiorgan failure and disseminated intravascular coagulation, and three developed acute respiratory distress syndromes. The inflammatory biomarkers in the first 3 days, including interleukin 6, ferritin, lactate dehydrogenase, and D-dimer, showed significant elevation in all cases. The hyperinflammatory response may play a role in the pathophysiology.

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Fatal Fulminant Cerebral Edema in Six Children With SARS-CoV-2 Omicron BA.2 Infection in Taiwan

Abstract

Keywords

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