Fascin-1: Updated biological functions and therapeutic implications in cancer biology

Chien Hsiu Li, Ming Hsien Chan, Shu Mei Liang, Yu Chan Chang*, Michael Hsiao

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Filopodia are cellular protrusions that respond to a variety of stimuli. Filopodia are formed when actin is bound to the protein Fascin, which may play a crucial role in cellular interactions and motility during cancer metastasis. Significantly, the noncanonical features of Fascin-1 are gradually being clarified, including the related molecular network contributing to metabolic reprogramming, chemotherapy resistance, stemness ac-tivity, and tumor microenvironment events. However, the relationship between biological characteristics and pathological features to identify effective therapeutic strategies needs to be studied further. The pur-pose of this review article is to provide a broad overview of the latest molecular networks and multiomics research regarding fascins and cancer. It also highlights their direct and indirect effects on available cancer treatments. With this multidisciplinary approach, researchers and clinicians can gain the most relevant in-formation on the function of fascins in cancer progression, which may facilitate clinical applications in the future.

Original languageEnglish
Article number100052
JournalBBA Advances
Volume2
DOIs
StatePublished - Jan 2022

Keywords

  • Bioinformatics
  • Cancer
  • Fascin
  • FSCN

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