Facial apocrine fibroadenoma in man: A rare finding

Han Nan Liu*, Yun Ting Chang, Chih Chiang Chen, An Han Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Apocrine fibroadenoma (AFA), considered a counterpart of fibroadenoma of breast, is a rare cutaneous apocrine neoplasm occurring almost exclusively in women. We describe a 75-year-old man who presented with a red dome-shaped papule near the nasal bridge. The tumor was composed of numerous tubular, cystic, and partially branching lumina and struts of epithelial cells oriented perpendicular to the skin surface, with which it connected through infundibula. The epithelial strands were embedded in fibrocollagenous stroma. These histopathological features are consistent with AFA. The cytokeratin profiles of our case were similar to those of apocrine or eccrine neoplasms. Progesterone and estrogen receptors (PR/ER) were not expressed. The stroma cells were stained strongly positive for vimentin, but nonreactive for α-smooth muscle actin, S-100 protein, or glial fibrillary acidic protein. To the best of our knowledge, this is the first report of facial AFA in man. Different from a more common anogenital AFA, this neoplasm might represent a second type of AFA with unique histopathologic and immunopathological features.

Original languageEnglish
Pages (from-to)274-278
Number of pages5
JournalAmerican Journal of Dermatopathology
Issue number3
StatePublished - Jun 2007


  • Apocrine fibroadenoma
  • Carcinoembryonic antigens
  • Cytokeratin
  • Myoepithelial cell markers
  • Vimentin


Dive into the research topics of 'Facial apocrine fibroadenoma in man: A rare finding'. Together they form a unique fingerprint.

Cite this