Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

Chi Hsiang Lien; Wen Shuo Kuo; Keng Chi Cho; Chun Yu Lin; Yuan Deng Su; Lynn L H Huang; Paul J. Campagnola; Chen Yuan Dong; Shean Jen Chen

doi:10.1364/OE.19.006260

Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

Chi Hsiang Lien^*, Wen Shuo Kuo, Keng Chi Cho, Chun Yu Lin, Yuan Deng Su, Lynn L H Huang, Paul J. Campagnola, Chen Yuan Dong, Shean Jen Chen

^*Corresponding author for this work

Institute of Imaging and Biomedical Photonics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

Original language	English
Pages (from-to)	6260-6268
Number of pages	9
Journal	Optics Express
Volume	19
Issue number	7
DOIs	https://doi.org/10.1364/OE.19.006260
State	Published - 28 Mar 2011

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title = "Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry",

abstract = "In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.",

author = "Lien, {Chi Hsiang} and Kuo, {Wen Shuo} and Cho, {Keng Chi} and Lin, {Chun Yu} and Su, {Yuan Deng} and Huang, {Lynn L H} and Campagnola, {Paul J.} and Dong, {Chen Yuan} and Chen, {Shean Jen}",

year = "2011",

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doi = "10.1364/OE.19.006260",

language = "English",

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T1 - Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

AU - Lien, Chi Hsiang

AU - Kuo, Wen Shuo

AU - Cho, Keng Chi

AU - Lin, Chun Yu

AU - Su, Yuan Deng

AU - Huang, Lynn L H

AU - Campagnola, Paul J.

AU - Dong, Chen Yuan

AU - Chen, Shean Jen

PY - 2011/3/28

Y1 - 2011/3/28

N2 - In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

AB - In this study, three-dimensional (3D) crosslinked bovine serum albumin (BSA) microstructures containing gold nanorods (AuNRs) were fabricated via multiphoton excited photochemistry using Rose Bengal (RB) as the photoactivator. To retain AuNRs in the 3D crosslinked BSA microstructures, the laser wavelength was chosen for two-photon RB absorption for improved two-photon crosslinking efficiency, but not for enhancing the longitudinal plasmon resonance of AuNRs which may result in photothermal damage of AuNRs. Furthermore, with two-photon excitation of RB via AuNRs plasmonics, the laser power can be reduced by about 30%. As a result, 3D BSA microstructures containing AuNRs can be successfully fabricated. The AuNRs-doped BSA microstructures can be applied in biomedical scaffolds with plasmonic properties such as two-photon luminescence imaging and photothermal therapy.

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SN - 1094-4087

VL - 19

SP - 6260

EP - 6268

JO - Optics Express

JF - Optics Express

IS - 7

ER -

Fabrication of gold nanorods-doped, bovine serum albumin microstructures via multiphoton excited photochemistry

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