Extreme Hypernatremia Combined With Rhabdomyolysis and Acute Renal Failure

Tzu Ying Yang, Jei Wen Chang, Min Hua Tseng, Hsin Hui Wang, Dau Ming Niu, Ling Yu Yang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Rhabdomyolysis is a life-threatening condition that involves muscle cell destruction. Among its etiologies, severe hyper-natremia is a less common cause. We report a teenage girl with congenital central hypoventilation syndrome and hypothalamus dysfunction syndrome who presented with extreme hypernatremia (sodium, 211 mmol/L) with rhabdomyolysis (creatine kinase, 32,850 U/L) and acute renal failure (creatinine, 6.1 mg/dL) following gastroenteritis with 7-kg weight loss. Rhabdomyolysis subsequently led to acute renal failure and hyperkalemia. Acute hemodialysis was initiated on hospital day 3 for hyperkalemia. This resulted in a 13 mmol/L fall in serum sodium in 3 hours despite using a 156 mmol/L sodium bath, but without the development of cerebral edema or neurological defect. This report highlights an unusual cause of rhabdomyolysis in children and the experience of managing such a difficult clinical situation. [J Chin Med Assoc 2009;72(10):555-558].

Original languageEnglish
Pages (from-to)555-558
Number of pages4
JournalJournal of the Chinese Medical Association
Issue number10
StatePublished - Oct 2009


  • acute renal failure
  • congenital central hypoventilation syndrome
  • hypernatremia
  • hypothalamus dysfunction syndrome
  • rhabdomyolysis


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