Extraction of quantitative optical properties from polarization-sensitive optical coherence tomography

Wen Chuan Kuo*, Ming Wei Hsiung, Po Nien Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In this research, we have developed an algorithm to extract four different optical parameters, including the scattering coefficient (μs), effective anisotropy factor (geff), birefringence coefficient (Δn), and fast-axis angle (β) from polarization-sensitive optical coherence tomography (PS-OCT) images. The proposed extraction algorithm was evaluated from a set of phantoms and it yielded valid results. The scattering coefficient and anisotropy factor can be used to describe the scattering effect and anisotropy characteristics of the sample. The birefringence property represents the difference between the tissue refractive indexes along the birefringent fast and slow axes, while the fast-axis angle can describe the fiber alignment of tissue. Finally, a preliminary ex vivo PS-OCT investigation on human aortic specimen indicated that the algorithm may contribute to differentiation between normal vessel and atherosclerotic plaques.

Original languageEnglish
Pages (from-to)191-197
Number of pages7
JournalJournal of Medical and Biological Engineering
Volume27
Issue number4
StatePublished - Dec 2007

Keywords

  • Anisotropy factor
  • Fast axis angle
  • Phase retardation
  • Scattering coefficient

Fingerprint

Dive into the research topics of 'Extraction of quantitative optical properties from polarization-sensitive optical coherence tomography'. Together they form a unique fingerprint.

Cite this