Expanding TRAF function: TRAF3 as a tri-faced immune regulator

Hans Häcker*, Ping Hui Tseng, Michael Karin

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

330 Scopus citations


Tumour necrosis factor receptor (TNFR)-associated factor (TRAF) proteins are essential components of signalling pathways activated by TNFR or Toll-like receptor (TLR) family members. Acting alone or in combination, the seven known TRAFs control many biological processes, including cytokine production and cell survival. The function of one TRAF in particular, TRAF3, remained elusive for many years. Recent work has revealed that TRAF3 is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein kinase activation and alternative nuclear factor-Î °B signalling. In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease.

Original languageEnglish
Pages (from-to)457-468
Number of pages12
JournalNature Reviews Immunology
Issue number7
StatePublished - Jul 2011


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