TY - JOUR
T1 - Expanding TRAF function
T2 - TRAF3 as a tri-faced immune regulator
AU - Häcker, Hans
AU - Tseng, Ping Hui
AU - Karin, Michael
N1 - Funding Information:
We thank P. Mehta for the bioinformatics analysis of the TRAF domain structures depicted in FIG. 1.H.H. was supported by US National Institutes of Health (NIH) grant AI083443 and the American Lebanese Syrian Associated Charities (ALSAC). Work was also supported by NIH grant AI043477 to M.K., who is an American Cancer Society Research Professor.
PY - 2011/7
Y1 - 2011/7
N2 - Tumour necrosis factor receptor (TNFR)-associated factor (TRAF) proteins are essential components of signalling pathways activated by TNFR or Toll-like receptor (TLR) family members. Acting alone or in combination, the seven known TRAFs control many biological processes, including cytokine production and cell survival. The function of one TRAF in particular, TRAF3, remained elusive for many years. Recent work has revealed that TRAF3 is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein kinase activation and alternative nuclear factor-Î °B signalling. In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease.
AB - Tumour necrosis factor receptor (TNFR)-associated factor (TRAF) proteins are essential components of signalling pathways activated by TNFR or Toll-like receptor (TLR) family members. Acting alone or in combination, the seven known TRAFs control many biological processes, including cytokine production and cell survival. The function of one TRAF in particular, TRAF3, remained elusive for many years. Recent work has revealed that TRAF3 is a highly versatile regulator that positively controls type I interferon production, but negatively regulates mitogen-activated protein kinase activation and alternative nuclear factor-Î °B signalling. In this Review, we discuss our current understanding of the role of TRAF3 in TNFR and TLR signalling pathways, and its role in disease.
UR - http://www.scopus.com/inward/record.url?scp=79959630000&partnerID=8YFLogxK
U2 - 10.1038/nri2998
DO - 10.1038/nri2998
M3 - Review article
C2 - 21660053
AN - SCOPUS:79959630000
SN - 1474-1733
VL - 11
SP - 457
EP - 468
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 7
ER -