Excitation Wavelength Independent Carbon-Decorated Ferrite Nanodots for Multimodal Diagnosis and Stimuli Responsive Therapy

Palani Sharmiladevi, Najim Akhtar, Viswanathan Haribabu, Koyeli Girigoswami, Surojit Chattopadhyay, Agnishwar Girigoswami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The combination of superparamagnetism and excitation independency have been packed into carbon-decorated ferrite nanodots (CDs@MNFs) for the introduction of a cost-effective and less-toxic multimodal contrast agent in fluorescence/MR imaging to replace conventional heavy metal containing Gd-DOTA. The label-free surface engineered ferrite nanodots are capable of generating twin T1 (longitudinal) and T2 (transverse) weighted magnetic resonance (MR) along with fluorescence emission. The calculated molar relaxivities and molar radiant efficiency obtained from in vitro and in vivo studies are the indication of its multimodal efficacy in medical imaging compared to the conventional contrast agents. The cellular internalization of nanodots was established by confocal microscopy and flow cytometric assay, whereas the hemolysis and cell viability assays support their appreciable toxicity. Furthermore, the surface chemistry due to the presence of -COOH was utilized to attach the anticancer agent, doxorubicin (-NH2) making it an external stimuli responsive drug delivery vehicle for the treatment of cancer. Given the ease of fabrication, negligible toxicity, and significant contrast enhancement with stimuli responsive drug release kinetics CDs@MNFs prove to be a potential, cost-effective multimodal imaging agent which could be used for theragnosis.

Original languageEnglish
Pages (from-to)1634-1642
Number of pages9
JournalACS Applied Bio Materials
Volume2
Issue number4
DOIs
StatePublished - 15 Apr 2019

Keywords

  • drug delivery
  • ferrite
  • multimodal imaging
  • nanodots
  • theragnosis
  • twin-relaxivity

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