@inproceedings{aac060fb6f2a4544bc9430fa159259cf,
title = "Evolutionary conservation of DNA-contact residues in DNA-binding domains",
abstract = "DNA-binding proteins are of utmost importance to gene regulation. The identification of DNA-binding domains is useful for understanding the regulation mechanisms of DNA-binding proteins. In this study, we proposed a method to determine whether a domain or a protein can has DNA binding capability by considering evolutionary conservation of DNA-binding residues. Our method achieves high precision and recall for 66 families of DNA-binding domains, with a false positive rate less than 5% for 250 non-DNA-binding proteins. In addition, experimental results show that our method is able to identify the different DNA-binding behaviors of proteins in the same SCOP family based on the use of evolutionary conservation of DNA-contact residues.",
author = "Chang, {Yao L.} and Tsai, {Huai Kuang} and Kao, {Cheng Y.} and Chen, {Yung Chian} and Jinn-Moon Yang",
year = "2007",
doi = "10.1109/IMSCCS.2007.4392574",
language = "English",
isbn = "0769530397",
series = "Proceedings - 2nd International Multi-Symposiums on Computer and Computational Sciences, IMSCCS'07",
pages = "9--16",
booktitle = "Proceedings - 2nd International Multi-Symposiums on Computer and Computational Sciences, IMSCCS'07",
note = "2nd International Multi-Symposiums on Computer and Computational Sciences 2007, IMSCCS'07 ; Conference date: 13-08-2007 Through 15-08-2007",
}