TY - JOUR
T1 - Evolution of the yeast protein interaction network
AU - Qint, Hong
AU - Lu, Henry H.S.
AU - Wu, Wei B.
AU - Li, Wen Hsiung
PY - 2003/10/28
Y1 - 2003/10/28
N2 - To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks.
AB - To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks.
UR - http://www.scopus.com/inward/record.url?scp=0242300098&partnerID=8YFLogxK
U2 - 10.1073/pnas.2235584100
DO - 10.1073/pnas.2235584100
M3 - Article
C2 - 14557537
AN - SCOPUS:0242300098
SN - 0027-8424
VL - 100
SP - 12820
EP - 12824
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 22
ER -