Evolution of the yeast protein interaction network

Hong Qint, Henry H.S. Lu, Wei B. Wu, Wen Hsiung Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


To study the evolution of the yeast protein interaction network, we first classified yeast proteins by their evolutionary histories into isotemporal categories, then analyzed the interaction tendencies within and between the categories, and finally reconstructed the main growth path. We found that two proteins tend to interact with each other if they are in the same or similar categories, but tended to avoid each other otherwise, and that network evolution mirrors the universal tree of life. These observations suggest synergistic selection during network evolution and provide insights into the hierarchical modularity of cellular networks.

Original languageEnglish
Pages (from-to)12820-12824
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - 28 Oct 2003


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