Evaluation of the epinecidin-1 peptide as an active ingredient in cleaning solutions against pathogens

Chieh Yu Pan, Venugopal Rajanbabu, Jyh Yih Chen*, Guor Mour Her, Fan Hua Nan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


We tested the activity of epinecidin-1, a novel antimicrobial peptide structurally related to pleurocidin, in commercial cleaning solutions stored at 4 and 25 °C for 7 and 14 days. The peptide's activities against Enterococcus faecalis, Escherichia coli, Klebsiella oxytoca, Pseudomonas aeruginosa, Staphylococcus aureus, Propionibacterium acnes, and Candida albicans were measured in a minimum inhibitory concentration (MIC) determination, minimal bactericidal concentration (MBC) determination, disk diffusion test, and a count of the bacterial numbers. Exposure to epinecidn-1 in a cleaning solution following MIC value comparisons in the disk diffusion test and counts of bacterial numbers after 16, 24, 48, and 72 h suggested that bacterial numbers were much lower than those treated with only commercial cleaning solutions for all bacteria. The efficacy of the antimicrobial activities of inhibiting bacterial numbers by epinecidin-1 in cleaning solutions at a low pH and a low temperature was not affected. Given its simple structure and antimicrobial activity, epinecidin-1 may be a useful component of microbicides designed to prevent pathogen infections and/or remediate abnormal vaginal or skin flora.

Original languageEnglish
Pages (from-to)1449-1458
Number of pages10
Issue number8
StatePublished - Aug 2010


  • Cleaning solution
  • Epinecidin-1
  • Gram-negative bacteria
  • Gram-positive bacteria
  • Lytic peptide


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