Evaluate the effects of kilovoltage transmission target X-ray equipment combined with radiosensitizers for Auger electron radiotherapy

Chin Hsiung Lin, Chen Ju Feng, Yuan Chun Lai, Shao Chun Tseng, Chin Hui Wu*, Shih Ming Hsu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Auger electrons are well-suited for targeted radiotherapy due to their ability to transfer high energy over short distances. Auger radiotherapy can be achieved by utilizing the characteristic radiation of transmission X-ray tubes and radiosensitizers to generate numerous Auger electrons. In this study, the Monte Carlo N-Particle (MCNP6) code was employed to simulate the deposition of dose in cells when combining the transmission X-ray tube with various concentrations of radiosensitizers. The results reveal that when the transmission X-ray tube is combined with 70 mg of gold nanoparticles (GNPs), the photoelectron flux is 1.16 × 103 (particles/cm2), which is 3.86 times higher than that observed with 0 mg of GNPs. Furthermore, the Auger electron flux is 3.51 × 102 (particles/cm2), representing a 15.51-fold increase compared to 0 mg of GNPs. The corresponding dose enhancement factor (DEF) is 3.14, representing the most substantial proportional increase observed. This study suggests that the combination of a transmission X-ray tube with appropriate radiosensitizers and concentrations can generate a significant number of photoelectrons and Auger electrons, resulting in a notable radio-enhancing effect. This innovative approach holds promise for the development of Auger radiotherapy as a potential therapeutic process. Future investigations could explore the optimal combination of transmission X-ray tubes and radiosensitizers to further advance the applications of Auger radiotherapy.

Original languageEnglish
Article number111320
JournalRadiation Physics and Chemistry
Volume215
DOIs
StatePublished - Feb 2024

Keywords

  • Auger electron
  • Dose enhancement factor
  • Monte Carlo
  • Radiosensitizers
  • Transmission X-ray tubes

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