Euthyroid sick syndrome after open heart surgery

Tsyr Yuh Ho, Pi Chang Lee, Zen Chung Weng, Ming Chih Tsai, Chi Ming Liang, Chih Yuan Lin, Chung Chang Laura Meng, Betau Hwang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: The hemodynamic effects of thyroid hormones are well documented, and include effects on cardiac contractility, heart rate and myocardial oxygen consumption. Major cardiac surgery under cardiopulmonary bypass (CPB) support may produce many alterations in endocrine homeostasis, which can exert substantial hemodynamic effects postoperatively. Twenty patients with various congenital heart diseases (CHDs) were enrolled to analyze their thyroid function before, during and after cardiac surgery. Materials and Methods: We found that there were short-term reversible postoperative declines in free thyroxine (T4), total T4, total tri-iodothyronine (TT3) and thyrotropin concentrations. TT3 decreased significantly from preoperative state to 30 min after the start of CPB (p = 0.007) and 1 day postoperatively (p = 0.008). The significant changes of the thyroid hormones in our 20 patients belonged to the euthyroid sick syndrome (ESS). There was no surgical complication and no need for thyroid hormone replacement. All these patients recovered and were discharged home smoothly. Conclusions: We conclude that patients with CHDs under cardiac surgery might present with ESS in postoperative period, but have no need for thyroid hormone replacement and will recover spontaneously within one week.

Original languageEnglish
Pages (from-to)207-213
Number of pages7
JournalActa Cardiologica Sinica
Issue number4
StatePublished - Dec 2005


  • Cardiac surgery
  • Cardiopulmonary bypass
  • Congenital heart disease
  • Euthyroid sick syndrome
  • Thyroid function


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