Estrogen effects on wound healing

Huann Cheng Horng; Wen Hsun Chang; Chang Ching Yeh; Ben Shian Huang; Chia Pei Chang; Yi Jen Chen; Kuan Hao Tsui; Peng Hui Wang

doi:10.3390/ijms18112325

Estrogen effects on wound healing

Huann Cheng Horng, Wen Hsun Chang, Chang Ching Yeh, Ben Shian Huang, Chia Pei Chang, Yi Jen Chen, Kuan Hao Tsui, Peng Hui Wang^*

^*Corresponding author for this work

Department of Obstetrics and Gynecology

Research output: Contribution to journal › Review article › peer-review

150 Scopus citations

Abstract

Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

Original language	English
Article number	2325
Journal	International Journal Of Molecular Sciences
Volume	18
Issue number	11
DOIs	https://doi.org/10.3390/ijms18112325
State	Published - 3 Nov 2017

Keywords

Estrogen
Estrogen receptor
Wound healing

Access to Document

10.3390/ijms18112325

Cite this

@article{fc93a308ef3445fd9716feeadd65e708,

title = "Estrogen effects on wound healing",

abstract = "Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.",

keywords = "Estrogen, Estrogen receptor, Wound healing",

author = "Horng, {Huann Cheng} and Chang, {Wen Hsun} and Yeh, {Chang Ching} and Huang, {Ben Shian} and Chang, {Chia Pei} and Chen, {Yi Jen} and Tsui, {Kuan Hao} and Wang, {Peng Hui}",

note = "Publisher Copyright: {\textcopyright} 2017 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2017",

month = nov,

day = "3",

doi = "10.3390/ijms18112325",

language = "English",

volume = "18",

journal = "International Journal Of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "11",

}

TY - JOUR

T1 - Estrogen effects on wound healing

AU - Horng, Huann Cheng

AU - Chang, Wen Hsun

AU - Yeh, Chang Ching

AU - Huang, Ben Shian

AU - Chang, Chia Pei

AU - Chen, Yi Jen

AU - Tsui, Kuan Hao

AU - Wang, Peng Hui

PY - 2017/11/3

Y1 - 2017/11/3

N2 - Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

AB - Wound healing is a physiological process, involving three successive and overlapping phases-hemostasis/inflammation, proliferation, and remodeling-to maintain the integrity of skin after trauma, either by accident or by procedure. Any disruption or unbalanced distribution of these processes might result in abnormal wound healing. Many molecular and clinical data support the effects of estrogen on normal skin homeostasis and wound healing. Estrogen deficiency, for example in postmenopausal women, is detrimental to wound healing processes, notably inflammation and re-granulation, while exogenous estrogen treatment may reverse these effects. Understanding the role of estrogen on skin might provide further opportunities to develop estrogen-related therapy for assistance in wound healing.

KW - Estrogen

KW - Estrogen receptor

KW - Wound healing

UR - http://www.scopus.com/inward/record.url?scp=85033563730&partnerID=8YFLogxK

U2 - 10.3390/ijms18112325

DO - 10.3390/ijms18112325

M3 - Review article

C2 - 29099810

AN - SCOPUS:85033563730

SN - 1661-6596

VL - 18

JO - International Journal Of Molecular Sciences

JF - International Journal Of Molecular Sciences

IS - 11

M1 - 2325

ER -

Estrogen effects on wound healing

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this