Abstract
Many biomedical studies involve the analysis of multiple events. The dependence between the times to these end points is often of scientific interest. We investigate a situation when one end point is subject to censoring by the other. The model assumptions of Day and co-workers and Fine and co-workers are extended to more general structures where the level of association may vary with time. Two types of estimating function are proposed. Asymptotic properties of the proposed estimators are derived. Their finite sample performance is studied via simulations. The inference procedures are applied to two real data sets for illustration.
Original language | English |
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Pages (from-to) | 257-273 |
Number of pages | 17 |
Journal | Journal of the Royal Statistical Society. Series B: Statistical Methodology |
Volume | 65 |
Issue number | 1 |
DOIs | |
State | Published - 1 Oct 2003 |
Keywords
- Archimedean copula models
- Bivariate survival analysis
- Competing risk
- Cross-ratio function
- Estimating function
- Frailty models
- Identifiability; Kendall's τ
- Log-rank statistic
- Multistate process
- Semi-competing-risks data
- Semiparametric inference