TY - JOUR
T1 - Estimating retinal nerve fiber layer thickness in normal schoolchildren with spectral-domain optical coherence tomography
AU - Tsai, Der Chong
AU - Huang, Nicole
AU - Hwu, Jinn Jong
AU - Jueng, Ruo Nan
AU - Chou, Pesus
N1 - Funding Information:
Acknowledgments This study was supported by the National Yang-Ming University Hospital (grant no.: RD2009-026).
PY - 2012/7
Y1 - 2012/7
N2 - Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal schoolchildren with spectral domain optical coherence tomography (SD-OCT), and to evaluate the effects of age, spherical equivalent (SE) refraction, OCT signal strength, and cycloplegic treatment on RNFL thickness. Methods: Comprehensive ophthalmic examinations were performed at a school visit. RNFL thicknesses were measured with RTVue-100 OCT. Refractive errors were measured by cycloplegic autorefraction. Results: Four hundred seventy healthy schoolchildren aged 7 and 12 were enrolled. The average RNFL thickness (mean ± SD) was 109.4 ± 10.0 μm. The quadrant RNFL thicknesses were 90.4 ± 14.3 μm (temporal), 142.2 ± 19.5 μm (inferior), 71.1 ± 11.3 μm (nasal), and 133.9 ± 18.1 μm (superior). After controlling for age, gender, cycloplegic treatment, and signal strength index, multiple linear regression analysis disclosed that only SE refraction has a significant effect on RNFL thickness, (p < 0.001). For every diopter change towards hyperopia, the average RNFL thickness increased by 1.7 μm. SE refraction was positively correlated with RNFL thickness in most sectors of nontemporal quadrants, but it was negatively correlated with RNFL thickness in sectors of temporal quadrants. Conclusions: Our study provides reference values of pediatric RNFL thickness measured with SD-OCT. SE refraction is the only significant predictor of RNFL thickness.
AB - Purpose: To measure the peripapillary retinal nerve fiber layer (RNFL) thickness in normal schoolchildren with spectral domain optical coherence tomography (SD-OCT), and to evaluate the effects of age, spherical equivalent (SE) refraction, OCT signal strength, and cycloplegic treatment on RNFL thickness. Methods: Comprehensive ophthalmic examinations were performed at a school visit. RNFL thicknesses were measured with RTVue-100 OCT. Refractive errors were measured by cycloplegic autorefraction. Results: Four hundred seventy healthy schoolchildren aged 7 and 12 were enrolled. The average RNFL thickness (mean ± SD) was 109.4 ± 10.0 μm. The quadrant RNFL thicknesses were 90.4 ± 14.3 μm (temporal), 142.2 ± 19.5 μm (inferior), 71.1 ± 11.3 μm (nasal), and 133.9 ± 18.1 μm (superior). After controlling for age, gender, cycloplegic treatment, and signal strength index, multiple linear regression analysis disclosed that only SE refraction has a significant effect on RNFL thickness, (p < 0.001). For every diopter change towards hyperopia, the average RNFL thickness increased by 1.7 μm. SE refraction was positively correlated with RNFL thickness in most sectors of nontemporal quadrants, but it was negatively correlated with RNFL thickness in sectors of temporal quadrants. Conclusions: Our study provides reference values of pediatric RNFL thickness measured with SD-OCT. SE refraction is the only significant predictor of RNFL thickness.
KW - Retinal nerve fiber layer thickness
KW - Schoolchildren
KW - Spectral-domain optical coherence tomography
UR - http://www.scopus.com/inward/record.url?scp=84863867546&partnerID=8YFLogxK
U2 - 10.1007/s10384-012-0142-7
DO - 10.1007/s10384-012-0142-7
M3 - Article
C2 - 22618665
AN - SCOPUS:84863867546
SN - 0021-5155
VL - 56
SP - 362
EP - 370
JO - Japanese Journal of Ophthalmology
JF - Japanese Journal of Ophthalmology
IS - 4
ER -