Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

Chun Yu Lin; Yi Ju Chen; Chih Hsuan Hsu; Yu Hsuan Lin; Peng Tzu Chen; Ting Han Kuo; Chris T. Ho; Hsin Hua Chen; Sih Jia Huang; Ho Chieh Chiu; Chin Chu Chen; Eric Hwang

doi:10.38212/2224-6614.3446

Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

Chun Yu Lin, Yi Ju Chen, Chih Hsuan Hsu, Yu Hsuan Lin, Peng Tzu Chen, Ting Han Kuo, Chris T. Ho, Hsin Hua Chen, Sih Jia Huang, Ho Chieh Chiu, Chin Chu Chen, Eric Hwang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.

Original language	English
Article number	3
Pages (from-to)	32-54
Number of pages	23
Journal	Journal of Food and Drug Analysis
Volume	31
Issue number	1
DOIs	https://doi.org/10.38212/2224-6614.3446
State	Published - 2023

Keywords

Axotomy
Bioactive
Erinacines
Neurodegenerative disease
Neurotrophic factor

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Lin, C. Y., Chen, Y. J., Hsu, C. H., Lin, Y. H., Chen, P. T., Kuo, T. H., Ho, C. T., Chen, H. H., Huang, S. J., Chiu, H. C., Chen, C. C., & Hwang, E. (2023). Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation. Journal of Food and Drug Analysis, 31(1), 32-54. Article 3. https://doi.org/10.38212/2224-6614.3446

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title = "Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation",

abstract = "Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.",

keywords = "Axotomy, Bioactive, Erinacines, Neurodegenerative disease, Neurotrophic factor",

author = "Lin, {Chun Yu} and Chen, {Yi Ju} and Hsu, {Chih Hsuan} and Lin, {Yu Hsuan} and Chen, {Peng Tzu} and Kuo, {Ting Han} and Ho, {Chris T.} and Chen, {Hsin Hua} and Huang, {Sih Jia} and Chiu, {Ho Chieh} and Chen, {Chin Chu} and Eric Hwang",

note = "Publisher Copyright: {\textcopyright} 2023 Taiwan Food and Drug Administration.",

year = "2023",

doi = "10.38212/2224-6614.3446",

language = "English",

volume = "31",

pages = "32--54",

journal = "Journal of Food and Drug Analysis",

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TY - JOUR

T1 - Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

AU - Lin, Chun Yu

AU - Chen, Yi Ju

AU - Hsu, Chih Hsuan

AU - Lin, Yu Hsuan

AU - Chen, Peng Tzu

AU - Kuo, Ting Han

AU - Ho, Chris T.

AU - Chen, Hsin Hua

AU - Huang, Sih Jia

AU - Chiu, Ho Chieh

AU - Chen, Chin Chu

AU - Hwang, Eric

PY - 2023

Y1 - 2023

N2 - Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.

AB - Erinacines derived from Hericium erinaceus have been shown to possess various health benefits including neuroprotective effect against neurodegenerative diseases, yet the underlying mechanism remains unknown. Here we found that erinacine S enhances neurite outgrowth in a cell autonomous fashion. It promotes post-injury axon regeneration of PNS neurons and enhances regeneration on inhibitory substrates of CNS neurons. Using RNA-seq and bioinformatic analyses, erinacine S was found to cause the accumulation of neurosteroids in neurons. ELISA and neurosteroidogenesis inhibitor assays were performed to validate this effect. This research uncovers a previously unknown effect of erinacine S on raising the level of neurosteroids.

KW - Axotomy

KW - Bioactive

KW - Erinacines

KW - Neurodegenerative disease

KW - Neurotrophic factor

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U2 - 10.38212/2224-6614.3446

DO - 10.38212/2224-6614.3446

M3 - Article

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AN - SCOPUS:85150390199

SN - 1021-9498

VL - 31

SP - 32

EP - 54

JO - Journal of Food and Drug Analysis

JF - Journal of Food and Drug Analysis

IS - 1

M1 - 3

ER -

Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation

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Keywords

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