Abstract
An 18-year-old woman presented with epileptic negative myoclonus (ENM) as her major seizure pattern for 4 years. Her seizures were characterized by intermittent postural lapse of the right limbs for a period of hours to 2 days. Ictal electroencephalography (EEG)-electromyography showed a silent period that was time-locked to generalized spike-wave discharges. Video/EEG monitoring demonstrated marked improvement of ENM after oral administration of levetiracetam. Cranial magnetic resonance imaging was normal, but 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography during frequent ENM showed hypometabolism in the left frontoparietal cortex. Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography revealed hyperperfusion over the left parietal cortex and putamen. Here, we document the short-term effects of levetiracetam in this subject with nearly isolated ENM and the neuroimaging results during ENM. Long-term follow-up is in progress to evaluate the clinical evolution and long-term effects of levetiracetam on ENM.
Original language | English |
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Pages (from-to) | 687-690 |
Number of pages | 4 |
Journal | Epilepsy and Behavior |
Volume | 14 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2009 |
Keywords
- 2-Deoxy-2-[F]fluoro-d-glucose positron emission tomography
- Epileptic negative myoclonus
- Levetiracetam
- Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography