Epileptic negative myoclonus: SPECT, PET, and video/EEG studies and the dramatic effects of levetiracetam

Hsiang Yu Yu*, Shang Yeong Kwan, Jiing Feng Lirng, Kwong Kum Liao, Yum Kung Chu, Shu Quinn Liao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

An 18-year-old woman presented with epileptic negative myoclonus (ENM) as her major seizure pattern for 4 years. Her seizures were characterized by intermittent postural lapse of the right limbs for a period of hours to 2 days. Ictal electroencephalography (EEG)-electromyography showed a silent period that was time-locked to generalized spike-wave discharges. Video/EEG monitoring demonstrated marked improvement of ENM after oral administration of levetiracetam. Cranial magnetic resonance imaging was normal, but 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography during frequent ENM showed hypometabolism in the left frontoparietal cortex. Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography revealed hyperperfusion over the left parietal cortex and putamen. Here, we document the short-term effects of levetiracetam in this subject with nearly isolated ENM and the neuroimaging results during ENM. Long-term follow-up is in progress to evaluate the clinical evolution and long-term effects of levetiracetam on ENM.

Original languageEnglish
Pages (from-to)687-690
Number of pages4
JournalEpilepsy and Behavior
Volume14
Issue number4
DOIs
StatePublished - Apr 2009

Keywords

  • 2-Deoxy-2-[F]fluoro-d-glucose positron emission tomography
  • Epileptic negative myoclonus
  • Levetiracetam
  • Technetium-99m-ethyl cysteinate dimer single-photon emission computed tomography

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