Enhancement of radiosurgical treatment outcome prediction using mri radiomics in patients with non-small cell lung cancer brain metastases

Chien Yi Liao, Cheng Chia Lee, Huai Che Yang, Ching Jen Chen, Wen Yuh Chung, Hsiu Mei Wu, Wan Yuo Guo, Ren Shyan Liu, Chia Feng Lu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The diagnosis of brain metastasis (BM) is commonly observed in non-small cell lung cancer (NSCLC) with poor outcomes. Accordingly, developing an approach to early predict BM response to Gamma Knife radiosurgery (GKRS) may benefit the patient treatment and monitoring. A total of 237 NSCLC patients with BMs (for survival prediction) and 256 patients with 976 BMs (for prediction of local tumor control) treated with GKRS were retrospectively analyzed. All the survival data were recorded without censoring, and the status of local tumor control was determined by comparing the last MRI follow-up in patients’ lives with the pre-GKRS MRI. Overall 1763 radiomic features were extracted from pre-radiosurgical magnetic resonance images. Three prediction models were constructed, using (1) clinical data, (2) radiomic features, and (3) clinical and radiomic features. Support vector machines with a 30% hold-out validation approach were constructed. For treatment outcome predictions, the models derived from both the clinical and radiomics data achieved the best results. For local tumor control, the combined model achieved an area under the curve (AUC) of 0.95, an accuracy of 90%, a sensitivity of 91%, and a specificity of 89%. For patient survival, the combined model achieved an AUC of 0.81, an accuracy of 77%, a sensitivity of 78%, and a specificity of 80%. The pre-radiosurgical radiomics data enhanced the performance of local tumor control and survival prediction models in NSCLC patients with BMs treated with GRKS. An outcome prediction model based on radiomics combined with clinical features may guide therapy in these patients.

Original languageEnglish
Article number4030
Issue number16
StatePublished - 2 Aug 2021


  • Brain metastasis
  • Gamma Knife radiosurgery
  • Machine learning
  • Magnetic resonance imaging
  • Non-small cell lung cancer
  • Outcome prediction
  • Radiomics


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