Emerging roles of epithelial-mesenchymal transition in hematological malignancies

San Chi Chen, Tsai Tsen Liao, Muh Hwa Yang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Background: Epithelial-mesenchymal transition is an important process in embryonic development, fibrosis, and cancer metastasis. During the progression of epithelial cancer, activation of epithelial-mesenchymal transition is tightly associated with metastasis, stemness and drug resistance. However, the role of epithelial-mesenchymal transition in non-epithelial cancer is relatively unclear. Main body: Epithelial-mesenchymal transition transcription factors are critical in both myeloid and lymphoid development. Growing evidence indicates their roles in cancer cells to promote leukemia and lymphoma progression. The expression of epithelial-mesenchymal transition transcription factors can cause the differentiation of indolent type to the aggressive type of lymphoma. Their up-regulation confers cancer cells resistant to chemotherapy, tyrosine kinase inhibitors, and radiotherapy. Conversely, the down-regulation of epithelial-mesenchymal transition transcription factors, monoclonal antibodies, induce lymphoma cells apoptosis. Conclusions: Epithelial-mesenchymal transition transcription factors are potentially important prognostic or predictive factors and treatment targets for leukemia and lymphoma.

Original languageEnglish
Article number37
JournalJournal of Biomedical Science
Issue number1
StatePublished - 23 Apr 2018


  • Epithelial-mesenchymal transition
  • Leukemia
  • Lymphoma


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