Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones

Richard B. Vallee; Garrett E. Seale; Jin Wu Tsai

doi:10.1016/j.tcb.2009.03.009

Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones

Richard B. Vallee^*, Garrett E. Seale, Jin Wu Tsai

^*Corresponding author for this work

Institute of Brain Science

Research output: Contribution to journal › Review article › peer-review

39 Scopus citations

Abstract

Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emphasis on migrating neurons and neuronal growth cones. The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles.

Original language	English
Pages (from-to)	347-355
Number of pages	9
Journal	Trends in Cell Biology
Volume	19
Issue number	7
DOIs	https://doi.org/10.1016/j.tcb.2009.03.009
State	Published - Jul 2009

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title = "Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones",

abstract = "Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emphasis on migrating neurons and neuronal growth cones. The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles.",

author = "Vallee, {Richard B.} and Seale, {Garrett E.} and Tsai, {Jin Wu}",

note = "Funding Information: We thank Mary Beth Hatten, Bruce Schaar, Susan McConnell and Paul Forscher for providing images for this article, and Silvia Cappello, Wei-Nan Lian, Timothy Petros, Richard McKenney and Kassandra Ori for critical reading of the manuscript and helpful suggestions. This work was supported by NIH Grants HD40182 and GM47434 and the March of Dimes Birth Defects Foundation.",

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AU - Vallee, Richard B.

AU - Seale, Garrett E.

AU - Tsai, Jin Wu

N1 - Funding Information: We thank Mary Beth Hatten, Bruce Schaar, Susan McConnell and Paul Forscher for providing images for this article, and Silvia Cappello, Wei-Nan Lian, Timothy Petros, Richard McKenney and Kassandra Ori for critical reading of the manuscript and helpful suggestions. This work was supported by NIH Grants HD40182 and GM47434 and the March of Dimes Birth Defects Foundation.

PY - 2009/7

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N2 - Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emphasis on migrating neurons and neuronal growth cones. The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles.

AB - Motor proteins are involved in a wide range of cellular and subcellular movements. Recent studies have implicated two motor proteins in particular, myosin II and cytoplasmic dynein, in diverse aspects of cell migration. This review focuses on emerging roles for these proteins in the nervous system, with particular emphasis on migrating neurons and neuronal growth cones. The former cells exhibit unusual features of centrosome and nuclear movement, whereas growth cones offer an opportunity to evaluate motor protein function in a region of cytoplasm free of these organelles.

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JO - Trends in Cell Biology

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ER -

Emerging roles for myosin II and cytoplasmic dynein in migrating neurons and growth cones

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