Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease: Friends or foes?

Ting Ting Chang, Jaw Wen Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.

Original languageEnglish
Article number117
JournalCardiovascular Diabetology
Volume15
Issue number1
DOIs
StatePublished - 24 Aug 2016

Keywords

  • Cardiovascular disease
  • Chemokine
  • Chemokine CC motif ligand 4
  • Diabetes mellitus
  • Fifth CC chemokine receptor

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