TY - JOUR
T1 - Emerging role of chemokine CC motif ligand 4 related mechanisms in diabetes mellitus and cardiovascular disease
T2 - Friends or foes?
AU - Chang, Ting Ting
AU - Chen, Jaw Wen
N1 - Publisher Copyright:
© 2016 The Author(s)
PY - 2016/8/24
Y1 - 2016/8/24
N2 - Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.
AB - Chemokines are critical components in pathology. The roles of chemokine CC motif ligand 4 (CCL4) and its receptor are associated with diabetes mellitus (DM) and atherosclerosis cardiovascular diseases. However, due to the complexity of these diseases, the specific effects of CCL4 remain unclear, although recent reports have suggested that multiple pathways are related to CCL4. In this review, we provide an overview of the role and potential mechanisms of CCL4 and one of its major receptors, fifth CC chemokine receptor (CCR5), in DM and cardiovascular diseases. CCL4-related mechanisms, including CCL4 and CCR5, might provide potential therapeutic targets in DM and/or atherosclerosis cardiovascular diseases.
KW - Cardiovascular disease
KW - Chemokine
KW - Chemokine CC motif ligand 4
KW - Diabetes mellitus
KW - Fifth CC chemokine receptor
UR - http://www.scopus.com/inward/record.url?scp=84983319977&partnerID=8YFLogxK
U2 - 10.1186/s12933-016-0439-9
DO - 10.1186/s12933-016-0439-9
M3 - Article
C2 - 27553774
AN - SCOPUS:84983319977
SN - 1475-2840
VL - 15
JO - Cardiovascular Diabetology
JF - Cardiovascular Diabetology
IS - 1
M1 - 117
ER -