Electrically responsive ZnO nanotubes for controlled release of biomolecules

C. C. Lin; Y. W. Chen; C. S. Hsiao; S. Y. Chen

doi:10.1016/j.ceramint.2017.05.299

Electrically responsive ZnO nanotubes for controlled release of biomolecules

C. C. Lin, Y. W. Chen, C. S. Hsiao, S. Y. Chen^*

^*Corresponding author for this work

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g⁻¹, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.

Original language	English
Pages (from-to)	S802-S806
Journal	Ceramics International
Volume	43
DOIs	https://doi.org/10.1016/j.ceramint.2017.05.299
State	Published - Aug 2017

Keywords

Drug release
Electrically responsive
Nanoresonators
ZnO nanotube

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10.1016/j.ceramint.2017.05.299

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title = "Electrically responsive ZnO nanotubes for controlled release of biomolecules",

abstract = "We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g−1, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.",

keywords = "Drug release, Electrically responsive, Nanoresonators, ZnO nanotube",

author = "Lin, {C. C.} and Chen, {Y. W.} and Hsiao, {C. S.} and Chen, {S. Y.}",

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month = aug,

doi = "10.1016/j.ceramint.2017.05.299",

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journal = "Ceramics International",

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T1 - Electrically responsive ZnO nanotubes for controlled release of biomolecules

AU - Lin, C. C.

AU - Chen, Y. W.

AU - Hsiao, C. S.

AU - Chen, S. Y.

PY - 2017/8

Y1 - 2017/8

N2 - We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g−1, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.

AB - We developed a novel electro-responsive drug delivery device by depositing fluorescein isothiocyanate (FITC)-loaded zinc oxide nanotubes (ZTs) onto indium tin oxide (ITO)/polyethylene terephthalate (PET) substrates (called FITC-ZTs-ITO/PET). With a large payload of FITC up to 0.98 mmol g−1, the FITC-ZTs simultaneously provide a burst-like FITC release and a repeated step-like release after application of an electrical field at specific resonant frequencies. Additionally, FITC-ZTs-ITO/PET is biocompatible with both HeLa and MRC5 cells for ZT concentrations below 50 μg/ml. These results demonstrate that FITC-ZTs-ITO/PET is a new platform that can provide local, on-demand electrically responsive drug release for biomedical applications.

KW - Drug release

KW - Electrically responsive

KW - Nanoresonators

KW - ZnO nanotube

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SN - 0272-8842

VL - 43

SP - S802-S806

JO - Ceramics International

JF - Ceramics International

ER -

Electrically responsive ZnO nanotubes for controlled release of biomolecules

Abstract

Keywords

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