Efficient flow fischer esterification of carboxylic acids with alcohols using sulfonic acid-functionalized silica as supported catalyst

Akihiro Furuta, Takahide Fukuyama, Ilhyong Ryu

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    19 Scopus citations

    Abstract

    Flow Fischer esterification of carboxylic acids using hydroxy-substituted sulfonic acid-functionalized silica (HOSAS) packed into a stainless steel column reactor was investigated. HO-SAS well catalyzed flow esterification of long chain carboxylic acids with methanol within 3min of residence time at 110°C, and the methyl esters were quantitatively obtained. The flow esterification protocol was applied to the synthesis of a variety of esters (19 examples) and scalable synthesis was also successful.

    Original languageEnglish
    Pages (from-to)607-612
    Number of pages6
    JournalBulletin of the Chemical Society of Japan
    Volume90
    Issue number5
    DOIs
    StatePublished - Jan 2017

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