TY - JOUR
T1 - Effects of Inferior Myocardial Infarction Sizes and Sites on Simulated Electrocardiograms Based on a Torso-Heart Model
AU - Cai, Zhipeng
AU - Li, Jianqing
AU - Luo, Kan
AU - Lin, Bor-Shyh
AU - Wang, Zhigang
AU - Zhang, Xiangyu
AU - Liu, Chengyu
PY - 2019/3/13
Y1 - 2019/3/13
N2 - Myocardial infarction (MI) is one of the major causes of death. Thus, understanding the underlying mechanisms of MI and its clinical features, especially its relationship with common electrocardiography measurements, is important. Heart modeling provides a possible method to simulate certain heart conditions. In this paper, a refined MI torso-heart model was proposed to explore the effect of inferior MI on simulated electrocardiograms. This model simulated the electrical activity of a normal heart and an inferior MI heart at three sites (basal, middle, and apical) with three MI sizes (small, moderate, and large), aiming to investigate the effect of inferior MI on the simulated electrocardiograms. Simulated body surface potential maps were compared with clinical body surface potential maps to verify the efficiency of the model. A new measure, namely, the normalized variation coefficient, was proposed for result evaluation. The results showed that the augmented unipolar left lower limb lead was the best choice for inferior MI diagnoses and it showed the most obvious electrocardiography signal differences between normal and inferior MI hearts. The simulation results corresponded well with commonly used clinical diagnostic criteria. Thus, the proposed refined MI torso-heart model provides a finite element simulation method for quantifying the effects of inferior MI on a torso-heart model-based electrocardiogram and has good potential for use in optimizing electrocardiogram detection.
AB - Myocardial infarction (MI) is one of the major causes of death. Thus, understanding the underlying mechanisms of MI and its clinical features, especially its relationship with common electrocardiography measurements, is important. Heart modeling provides a possible method to simulate certain heart conditions. In this paper, a refined MI torso-heart model was proposed to explore the effect of inferior MI on simulated electrocardiograms. This model simulated the electrical activity of a normal heart and an inferior MI heart at three sites (basal, middle, and apical) with three MI sizes (small, moderate, and large), aiming to investigate the effect of inferior MI on the simulated electrocardiograms. Simulated body surface potential maps were compared with clinical body surface potential maps to verify the efficiency of the model. A new measure, namely, the normalized variation coefficient, was proposed for result evaluation. The results showed that the augmented unipolar left lower limb lead was the best choice for inferior MI diagnoses and it showed the most obvious electrocardiography signal differences between normal and inferior MI hearts. The simulation results corresponded well with commonly used clinical diagnostic criteria. Thus, the proposed refined MI torso-heart model provides a finite element simulation method for quantifying the effects of inferior MI on a torso-heart model-based electrocardiogram and has good potential for use in optimizing electrocardiogram detection.
KW - Biomedical engineering
KW - biomedical signal processing
KW - computational modeling
KW - computer simulation
KW - electrocardiography
KW - finite element methods
KW - signal analysis
KW - signal processing
UR - http://www.scopus.com/inward/record.url?scp=85063942837&partnerID=8YFLogxK
U2 - 10.1109/ACCESS.2019.2904707
DO - 10.1109/ACCESS.2019.2904707
M3 - Article
AN - SCOPUS:85063942837
SN - 2169-3536
VL - 7
SP - 35470
EP - 35479
JO - IEEE Access
JF - IEEE Access
IS - 1
M1 - 8666980
ER -