Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis

S. J. Wang; J. L. Lan; J. L. Lan; D. Y. Chen; Y. H. Chen; T. Y. Hsieh; W. Y. Lin

doi:10.1007/s100670200010

Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis

S. J. Wang^*, J. L. Lan, J. L. Lan, D. Y. Chen, Y. H. Chen, T. Y. Hsieh, W. Y. Lin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.

Original language	English
Pages (from-to)	43-45
Number of pages	3
Journal	Clinical Rheumatology
Volume	21
Issue number	1
DOIs	https://doi.org/10.1007/s100670200010
State	Published - 2002

Keywords

Cisapride
Motility
Oesophageal transit study
Progressive systemic sclerosis

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10.1007/s100670200010

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title = "Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis",

abstract = "In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.",

keywords = "Cisapride, Motility, Oesophageal transit study, Progressive systemic sclerosis",

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AU - Hsieh, T. Y.

AU - Lin, W. Y.

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AB - In most patients with progressive systemic sclerosis (PSS) the oesophagus is affected. Reflux symptoms are most frequent, whilst dysphagia also occurs. Cisapride, a prokinetic agent, may enhance motility along the gastrointestinal tract. The effects of cisapride on oesophageal transit were evaluated in 12 PSS patient using a solid-phase radionuclide oesophageal transit study. Each PSS patient was given cisapride 10 mg or placebo orally three times a day in a random, double-blind, crossover fashion. The results show that cisapride does not seem to have any impact on oesophageal transit in patients with PSS.

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Effects of cisapride on oesophageal transit of solids in patients with progressive systemic sclerosis

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Keywords

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