Effects of cisapride on colonic transit in patients with progressive systemic sclerosis

S. J. Wang*, J. L. Lan, J. L. Lan, D. Y. Chen, Y. H. Chen, T. Y. Hsieh, W. Y. Lin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Progressive systemic sclerosis (PSS) may involve any portion of the gastrointestinal tract, including the colon. Constipation is common in patients with PSS. Cisapride, a benzamide derivative, is a potentially useful agent in the treatment of chronic idiopathic constipation. The effect of cisapride on colonic transit was evaluated in 16 PSS patients by a radionuclide colonic transit method. Each patient received cisapride orally three times a day for a week. The results showed acceleration in colonic transit in response to cisapride. We conclude that cisapride is effective in the treatment of constipation in patients with PSS.

Original languageEnglish
Pages (from-to)271-274
Number of pages4
JournalClinical Rheumatology
Volume21
Issue number4
DOIs
StatePublished - Aug 2002

Keywords

  • Cisapride
  • Colon
  • Progressive systemic sclerosis

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