Effects of a high-fat/high-sucrose diet on cortical bone remodeling and biomechanics

Kung Chia Li*, Ronald F. Zernicke, R. James Barnard, Anna F.Y. Li

*Corresponding author for this work

Research output: Contribution to journalConference articlepeer-review

Abstract

High-fat/high-sucrose (HFS) diet has been reported to cause glucose intolerance and hyperinsulinemia which may have deleterious effects on bone (e.g., hypercaliciuria). Effects of high-fat diet on calcium absorption and bone calcium content remain controversial, however. Thus we examined the biomechanical and histological responses in limb bones of rats fed a HFS diet. The right tibia and second metatarsus (MT) were tested in three-point bending to failure, and contralateral bones were used for geometrical and histological analyses. Mechanically, HFS tibia had significantly lower maximum load and failure energy. The linear tensile stress for both HFS MT and tibia decreased significantly. In addition, the elastic modulus of the HFS metatarsal bone was significantly lower than control. The middiaphyseal cross-sectional geometry of tibia was unaffected, nevertheless, the dorsal-cortical thickness of MT increased significantly. Histologically, the number of osteocytes and osteoclasts decreased significantly in tibial middiaphysis. The number of Haversian-systems-like structures, osteocytes, and osteoclast decreased significantly and the inert areas increased significantly. Results suggested that a HFS diet decreased cortical bone mechanical properties and the potential for bone modeling and remodeling.

Original languageEnglish
Pages (from-to)1046
Number of pages1
JournalJournal of Biomechanics
Volume22
Issue number10
DOIs
StatePublished - 1989
EventAbstracts of the XII Congress, International Society of Biomechanics - Los Angeles, CA, USA
Duration: 26 Jun 198930 Jun 1989

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