Effectiveness and Safety of Standard- and Low-Dose Rivaroxaban in Asians With Atrial Fibrillation

Yi Cheng Lin, Shu Chen Chien, Yi Chen Hsieh, Chun Ming Shih, Feng Yen Lin, Nai Wen Tsao, Chih Wei Chen, Yung Ta Kao, Kuang Hsing Chiang, Wan Ting Chen, Li Nien Chien, Chun Yao Huang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Background: Low-dose rivaroxaban (10 mg/day) has been widely used in Asia for patients with atrial fibrillation (AF), although there is a lack of evidence regarding its effectiveness. In Asians, it is unclear whether low-dose rivaroxaban is equally effective as that of the standard dose or is associated with less bleeding risk. Objectives: The aim of this study was to evaluate the effectiveness and safety of standard-dose (15 or 20 mg/day) and low-dose (10 mg/day) rivaroxaban in Asians with AF. Methods: Using data files from the National Health Insurance Research Database between May 1, 2014, and September 30, 2015, a retrospective population-based cohort study was conducted in patients diagnosed with AF or atrial flutter and treated with low- or standard-dose rivaroxaban. Patients were followed up until the first occurrence of the study outcome or the end of the observation period (December 31, 2015). Results: Among 6,558 eligible patients, a total of 2,373 and 4,185 patients took low- and standard-dose rivaroxaban, respectively. Compared to standard-dose rivaroxaban, low-dose rivaroxaban was associated with a significantly higher risk of myocardial infarction (subdistribution hazard ratio: 2.26; 95% confidence interval: 1.13 to 4.52), with similar risk of ischemic stroke, systemic embolism, major bleeding, and nonmajor clinically relevant bleeding. Conclusions: Compared to standard-dose rivaroxaban, low-dose rivaroxaban in Asian patients with AF was associated with similar risks of thromboembolism and bleeding except myocardial infarction.

Original languageEnglish
Pages (from-to)477-485
Number of pages9
JournalJournal of the American College of Cardiology
Issue number5
StatePublished - 31 Jul 2018


  • bleeding
  • embolism
  • myocardial infarction
  • non–vitamin K antagonist oral anticoagulant
  • stroke


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