TY - JOUR
T1 - Effective suppression of myocardial glucose uptake using predesigned low-carbohydrate boxed meals
AU - Huang, Cheng Kai
AU - Hou, Po Nien
AU - Luzhbin, Dmytro
AU - Yang, Chao Wei
AU - Chang, Yu Ting
AU - Wu, Jay
N1 - Publisher Copyright:
© 2022, The Author(s) under exclusive licence to American Society of Nuclear Cardiology.
PY - 2022
Y1 - 2022
N2 - Background: Dietary preparation protocols are an effective means to suppress physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake. This study aimed to investigate the efficacy of various carbohydrate-restricted diets using predesigned boxed meals. Methods: The patients were divided into four groups to undergo different preparatory protocols as follows: a minimum 15-hours fast alone, two meals of high-fat, low-carbohydrate diet (HFLCD), two meals of high-animal-protein, low-carbohydrate diet (HAPLCD), and two meals of high-plant-based-protein, low-carbohydrate diet (HPPLCD). Boxed meals were prepared to meet the required carbohydrate restrictions. Myocardial SUVmax and SUVmean were measured and the suppression rate was analyzed. Results: The average myocardial SUVmax of fast alone, HFLCD, HAPLCD, and HPPLCD was 8.26 ± 5.85, 2.21 ± 1.50, 2.34 ± 1.88, and 4.10 ± 3.61, respectively, and the suppression rate was 36.6%, 93.3%, 93.3%, and 70%, respectively. The effectiveness of HFLCD, HAPLCD, and HPPLCD was all statistically superior to that of a 15-hours fast alone. SUVmax of HFLCD and HAPLCD showed no significant differences (p = 1), whereas HFLCD and HPPLCD had significant differences (p =.046). Conclusions: Using the predesigned boxed meals based on carbohydrate restriction, HFLCD, HAPLCD, and HPPLCD can be administered to patients with different dietary needs, while providing a substantial reduction in physiological myocardial FDG uptake.
AB - Background: Dietary preparation protocols are an effective means to suppress physiological myocardial 18F-fluorodeoxyglucose (FDG) uptake. This study aimed to investigate the efficacy of various carbohydrate-restricted diets using predesigned boxed meals. Methods: The patients were divided into four groups to undergo different preparatory protocols as follows: a minimum 15-hours fast alone, two meals of high-fat, low-carbohydrate diet (HFLCD), two meals of high-animal-protein, low-carbohydrate diet (HAPLCD), and two meals of high-plant-based-protein, low-carbohydrate diet (HPPLCD). Boxed meals were prepared to meet the required carbohydrate restrictions. Myocardial SUVmax and SUVmean were measured and the suppression rate was analyzed. Results: The average myocardial SUVmax of fast alone, HFLCD, HAPLCD, and HPPLCD was 8.26 ± 5.85, 2.21 ± 1.50, 2.34 ± 1.88, and 4.10 ± 3.61, respectively, and the suppression rate was 36.6%, 93.3%, 93.3%, and 70%, respectively. The effectiveness of HFLCD, HAPLCD, and HPPLCD was all statistically superior to that of a 15-hours fast alone. SUVmax of HFLCD and HAPLCD showed no significant differences (p = 1), whereas HFLCD and HPPLCD had significant differences (p =.046). Conclusions: Using the predesigned boxed meals based on carbohydrate restriction, HFLCD, HAPLCD, and HPPLCD can be administered to patients with different dietary needs, while providing a substantial reduction in physiological myocardial FDG uptake.
KW - Carbohydrate restriction
KW - dietary preparation
KW - FDG
KW - PET/CT
UR - http://www.scopus.com/inward/record.url?scp=85135336775&partnerID=8YFLogxK
U2 - 10.1007/s12350-022-03076-4
DO - 10.1007/s12350-022-03076-4
M3 - Article
C2 - 35918591
AN - SCOPUS:85135336775
SN - 1071-3581
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
ER -