Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang, Peng Nien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yun Ming Wang, Shin Ru Shih, John Tsu An Hsu*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    Abstract

    We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

    Original languageEnglish
    Article numbere00695-20
    JournalAntimicrobial Agents and Chemotherapy
    Volume65
    Issue number1
    DOIs
    StatePublished - Jan 2021

    Keywords

    • Antiviral research
    • Decoy receptor
    • Enterovirus A71
    • Neuropilin 1
    • Virus receptor trap

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