Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang; Peng Nien Huang; Hui Chen Hung; Sung Nien Tseng; Chia Chia Chang; Ya Ru Tsai; Yun Ming Wang; Shin Ru Shih; John Tsu An Hsu

doi:10.1128/AAC.00695-20

Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Hsiang Ching Wang, Peng Nien Huang, Hui Chen Hung, Sung Nien Tseng, Chia Chia Chang, Ya Ru Tsai, Yun Ming Wang, Shin Ru Shih, John Tsu An Hsu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

Original language	English
Article number	e00695-20
Pages (from-to)	1-8
Number of pages	8
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	1
DOIs	https://doi.org/10.1128/AAC.00695-20
State	Published - Jan 2021

Keywords

Antiviral research
Decoy receptor
Enterovirus A71
Neuropilin 1
Virus receptor trap

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.00695-20

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title = "Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro",

abstract = "We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.",

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AU - Wang, Hsiang Ching

AU - Huang, Peng Nien

AU - Hung, Hui Chen

AU - Tseng, Sung Nien

AU - Chang, Chia Chia

AU - Tsai, Ya Ru

AU - Wang, Yun Ming

AU - Shih, Shin Ru

AU - Hsu, John Tsu An

PY - 2021/1

Y1 - 2021/1

N2 - We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

AB - We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.

KW - Antiviral research

KW - Decoy receptor

KW - Enterovirus A71

KW - Neuropilin 1

KW - Virus receptor trap

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AN - SCOPUS:85098637216

SN - 0066-4804

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IS - 1

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ER -

Effect of a neuropilin-1-derived virus receptor trap on enterovirus a71 infection in vitro

Abstract

Keywords

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