Eco-friendly, bright luminescent carbon dots and their potential applications for detecting hypochlorous acid in water and live cell imaging

Parthiban Venkatesan, Rajakumar Govindasamy, Govindasami Periyasami, Mostafizur Rahaman, Saravanan Pandiaraj, Muthu Thiruvengadam, Natesan Thirumalaivasan*, Shu Pao Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

In this study, we utilized Agaricaceae, or mushrooms, as the carbon source for the hydrothermal production of multifunctional carbon dots (MCDs). The MCDs showed remarkable features such as bright blue fluorescence, exceptional biocompatibility, high quantum yield, and efficient biolabeling ability. Moreover, the MCDs displayed extraordinary specificity towards HOCl, and could detect it in deionized water with a lower detection limit of 3.38 nM. Additionally, the MCDs had potent antioxidant properties, low cytotoxicity, and high cell permeability, as confirmed by DPPH and reducing potential analysis. Furthermore, the MCD probe proved to be highly useful in various biological applications, including the detection of endogenous HOCl in the RAW 264.7 cell line and the assessment of PMA-induced endogenous HOCl formation using confocal imaging. The synthesis of carbon dots (CDs) from a natural resource such as mushrooms is a promising prospect due to their exceptional physicochemical properties and broad range of potential applications.

Original languageEnglish
Pages (from-to)6522-6532
Number of pages11
JournalJournal of Materials Research and Technology
Volume24
DOIs
StatePublished - 1 May 2023

Keywords

  • Antioxidant
  • Biocompatibility
  • Carbon dot
  • Cell imaging
  • Fluorescent character
  • Green synthesis
  • Hypochlorous acid

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