Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy

Pei Wei Shueng; Lu Yi Yu; Hsin Cheng Chiu; Hui Ching Chang; Yen Ling Chiu; Tzu Yu Kuo; Yu Wei Yen; Chun Liang Lo

doi:10.1016/j.biomaterials.2021.121012

Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy

Pei Wei Shueng, Lu Yi Yu, Hsin Cheng Chiu, Hui Ching Chang, Yen Ling Chiu, Tzu Yu Kuo, Yu Wei Yen, Chun Liang Lo^*

^*Corresponding author for this work

Department of Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Recent studies have indicated that cancer treatment based on immunotherapy alone is not viable. Combined treatment with other strategies is required to achieve the expected therapeutic effect. Reactive oxygen species (ROS) play an important role in regulating cancer cells and the tumor microenvironment, even in immune cells. However, rigorous regulation of the ROS level within the entire tumor tissue is difficult, limiting the application of ROS in cancer therapy. Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy.

Original language	English
Article number	121012
Journal	Biomaterials
Volume	276
DOIs	https://doi.org/10.1016/j.biomaterials.2021.121012
State	Published - Sep 2021

Keywords

Chemotherapy
Immunotherapy
Phago-/endosomal escape
Polymeric micelles
Tumor-associated macrophages

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biomaterials.2021.121012

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@article{e2e58ea84a7746c38e83cdec7e68c12d,

title = "Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy",

abstract = "Recent studies have indicated that cancer treatment based on immunotherapy alone is not viable. Combined treatment with other strategies is required to achieve the expected therapeutic effect. Reactive oxygen species (ROS) play an important role in regulating cancer cells and the tumor microenvironment, even in immune cells. However, rigorous regulation of the ROS level within the entire tumor tissue is difficult, limiting the application of ROS in cancer therapy. Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy.",

keywords = "Chemotherapy, Immunotherapy, Phago-/endosomal escape, Polymeric micelles, Tumor-associated macrophages",

author = "Shueng, {Pei Wei} and Yu, {Lu Yi} and Chiu, {Hsin Cheng} and Chang, {Hui Ching} and Chiu, {Yen Ling} and Kuo, {Tzu Yu} and Yen, {Yu Wei} and Lo, {Chun Liang}",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = sep,

doi = "10.1016/j.biomaterials.2021.121012",

language = "English",

volume = "276",

journal = "Biomaterials",

issn = "0142-9612",

publisher = "Elsevier BV",

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T1 - Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy

AU - Shueng, Pei Wei

AU - Yu, Lu Yi

AU - Chiu, Hsin Cheng

AU - Chang, Hui Ching

AU - Chiu, Yen Ling

AU - Kuo, Tzu Yu

AU - Yen, Yu Wei

AU - Lo, Chun Liang

PY - 2021/9

Y1 - 2021/9

N2 - Recent studies have indicated that cancer treatment based on immunotherapy alone is not viable. Combined treatment with other strategies is required to achieve the expected therapeutic effect. Reactive oxygen species (ROS) play an important role in regulating cancer cells and the tumor microenvironment, even in immune cells. However, rigorous regulation of the ROS level within the entire tumor tissue is difficult, limiting the application of ROS in cancer therapy. Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy.

AB - Recent studies have indicated that cancer treatment based on immunotherapy alone is not viable. Combined treatment with other strategies is required to achieve the expected therapeutic effect. Reactive oxygen species (ROS) play an important role in regulating cancer cells and the tumor microenvironment, even in immune cells. However, rigorous regulation of the ROS level within the entire tumor tissue is difficult, limiting the application of ROS in cancer therapy. Therefore, we design an early phago-/endosome-escaping micelle that can release platinum-based drugs into the cytoplasm of macrophages and cancer cells, thereby enhancing the ROS levels of the entire tumor tissue; inducing apoptosis of cancer cells, down-regulation of CD47 expression of cancer cells, polarization of M1 macrophages, and phagocytosis of cancer cells by M1 macrophages; and achieving the dual effect of chemotherapy and macrophage-mediated immunotherapy.

KW - Chemotherapy

KW - Immunotherapy

KW - Phago-/endosomal escape

KW - Polymeric micelles

KW - Tumor-associated macrophages

UR - http://www.scopus.com/inward/record.url?scp=85109572807&partnerID=8YFLogxK

U2 - 10.1016/j.biomaterials.2021.121012

DO - 10.1016/j.biomaterials.2021.121012

M3 - Article

C2 - 34252800

AN - SCOPUS:85109572807

SN - 0142-9612

VL - 276

JO - Biomaterials

JF - Biomaterials

M1 - 121012

ER -

Early phago-/endosomal escape of platinum drugs via ROS-responsive micelles for dual cancer chemo/immunotherapy

Abstract

Keywords

UN SDGs

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