@inproceedings{4abf86bb1c1347c188fcc205ac5a70e2,
title = "Dynamic contrast-enhanced magnetic resonance angiography of Gd-TTDA-BOM and Gd-DTPA at 3T in a normal rat model",
abstract = "Gd-TTDA-BOM is designed to be a paramagnetic contrast agent for magnetic resonance imaging (MRI). The ligand TTDA-BOM includes a benzyloxymethyl group to raise the lipophilicity. It is known that Gd-TTDA-BOM has faster water exchange rate and higher reorientational time than Gd-DTPA. It also has high bound relaxivity with human serum albumin (HSA). This study first evaluated the relaxivity values of Gd-TTDA-BOM and Gd-DTPA solutions with 4.5% HSA and then investigated the signal enhancement of dynamic contrast-enhanced magnetic resonance angiography after Gd-TTDA-BOM or Gd-DTPA bolus injection in a normal rat model. A 3T whole-body MR scanner providing higher signal to noise ratios (SNR) than 1.5T was used. The results showed that Gd-TTDA-BOM with HSA had higher relaxivity values than Gd-DTPA with HSA. Gd-TTDA-BOM also caused higher and longer signal enhancement in aorta than Gd-DTPA. It is concluded that Gd-TTDA-BOM has a good potential to be a blood pool MRI contrast agent.",
keywords = "3T, Gd-DTPA, Gd-TTDA-BOM, contrast agents, magnetic resonance angiography, rat",
author = "Jao, {Jo Chi} and Chen, {Yen Ku} and Jaw, {Twei Shiun} and Yun-Ming Wang and Chen, {Po Chou}",
year = "2012",
doi = "10.1109/iCBEB.2012.162",
language = "English",
isbn = "9780769547060",
series = "Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012",
pages = "781--783",
booktitle = "Proceedings - 2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012",
note = "2012 International Conference on Biomedical Engineering and Biotechnology, iCBEB 2012 ; Conference date: 28-05-2012 Through 30-05-2012",
}