Dye- A nd dye-doped liquid crystals in biosensing

Mon Juan Lee, Yi Lun Chiang, Abhishek Karn, Po Chang Wu, Wei Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations


Liquid crystals (LCs) have been suggested to have a place in biological sensing for detection and quantitation of biomolecules. Through many years, texture observation has long been the core technique in LC-based bioassays. Its principle stems from the texture change of LCs due to the interruption of the initially homeotropic alignment in nematic bulks or the radial-to-bipolar configuration transition in LC droplets in the presence of biomolecules. Biodetection through optical texture observation is convenient but remains a qualitative method, and alternative approaches of detection and quantitative analysis are necessary for the development of a practical LC-based biosensor. In this study, we explore the potential of two dye-enhanced LCs, a dye LC (DLC) and a dye-doped LC (DDLC), in biosensing and protein quantitation. Depending on the chromophore or dye incorporated in DLC and DDLC, the dichroic features of these LCs enable us to analyze the change in their orientation in the presence of biomolecules by transmission spectrometry, from which spectral parameters are derived to establish novel LC-based protein quantitative methods.

Original languageEnglish
Title of host publicationLiquid Crystals XXII
EditorsIam Choon Khoo
ISBN (Electronic)9781510620414
StatePublished - 1 Jan 2018
EventLiquid Crystals XXII 2018 - San Diego, United States
Duration: 19 Aug 201820 Aug 2018

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X


ConferenceLiquid Crystals XXII 2018
Country/TerritoryUnited States
CitySan Diego


  • Biophotonics
  • Biosensors
  • Dye-doped liquid crystals
  • Dye-liquid crystals
  • Liquid crystals
  • Polarized light
  • Transmission spectroscopy


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