Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study

Po Han Chou; Wei Hao Lin; Chih Chien Lin; Po Hsun Hou; Wan Rung Li; Chia Chun Hung; Ching Po Lin; Tsuo Hung Lan; Chin Hong Chan

doi:10.1038/srep18069

Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study

Po Han Chou^*, Wei Hao Lin, Chih Chien Lin, Po Hsun Hou, Wan Rung Li, Chia Chun Hung, Ching Po Lin, Tsuo Hung Lan, Chin Hong Chan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.

Original language	English
Article number	18069
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep18069
State	Published - 10 Dec 2015

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title = "Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study",

abstract = "A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.",

author = "Chou, {Po Han} and Lin, {Wei Hao} and Lin, {Chih Chien} and Hou, {Po Hsun} and Li, {Wan Rung} and Hung, {Chia Chun} and Lin, {Ching Po} and Lan, {Tsuo Hung} and Chan, {Chin Hong}",

note = "Funding Information: We thank Kai-Dih Juang and Yu-Chen Lin for their assessments of clinical information of study participants. This study was supported in part by grants from Taichung Veterans General Hospital, Taiwan (TCVGH-1034001A, TCVGH-1044002B, and TCVGH-YM1040101).",

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doi = "10.1038/srep18069",

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T2 - A Near-Infrared Spectroscopy Study

AU - Chou, Po Han

AU - Lin, Wei Hao

AU - Lin, Chih Chien

AU - Hou, Po Hsun

AU - Li, Wan Rung

AU - Hung, Chia Chun

AU - Lin, Ching Po

AU - Lan, Tsuo Hung

AU - Chan, Chin Hong

N1 - Funding Information: We thank Kai-Dih Juang and Yu-Chen Lin for their assessments of clinical information of study participants. This study was supported in part by grants from Taichung Veterans General Hospital, Taiwan (TCVGH-1034001A, TCVGH-1044002B, and TCVGH-YM1040101).

PY - 2015/12/10

Y1 - 2015/12/10

N2 - A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.

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Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study

Abstract

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