Down-regulation of aryl hydrocarbon receptor intensifies carcinogen-induced retinal lesion via SOCS3-STAT3 signaling

Keyphrases

• Signal Transducer and Activator of Transcription 3 100%
• Suppressor of Cytokine Signaling 3 (SOCS3) 100%
• Retinal Lesions 100%
• Carcinogen-induced 100%
• Aryl Hydrocarbon Receptor 100%
• B(a)P 41%
• Inflammation 16%
• Retina 16%
• Homeostasis 16%
• Benzo(a)pyrene 16%
• ARPE-19 Cells 16%
• Receptor Function 16%
• High Activity 8%
• Blockage 8%
• Major Risk 8%
• Metabolism 8%
• Cigarette Smoking 8%
• Xenobiotics 8%
• Long-term Exposure 8%
• Carcinogen 8%
• Retinal pigment Epithelium 8%
• Disintegration 8%
• Receptor Expression 8%
• Visual Function 8%
• Activating Receptors 8%
• Ubiquitination 8%
• Hypo 8%
• Negative Feedback Regulation 8%
• Knockout Cells 8%
• Severe Inflammation 8%
• Retinal Damage 8%
• Retina Thickness 8%
• Receptor Knockout 8%
• ARPE-19 8%
• Xenobiotic Exposure 8%
• Cigarette Smoking Exposure 8%
• Ocular Inflammation 8%
• Human Adult 8%
• Nifuroxazide 8%
• Pro-inflammation 8%
• Lesion Development 8%

Pharmacology, Toxicology and Pharmaceutical Science

• Carcinogen 100%
• STAT3 Protein 100%
• Suppressor of Cytokine Signaling 3 100%
• Aromatic Hydrocarbon Receptor 100%
• Inflammation 25%
• Xenobiotic Agent 16%
• Retina Injury 16%
• Benzo(a)pyrene 16%
• Receptor 8%
• Cigarette Smoke 8%
• Long Term Exposure 8%
• Cigarette Smoking 8%
• Visual Pigment 8%
• Eye Inflammation 8%
• Nifuroxazide 8%
• Retinitis 8%